Revista de Gastroenterología de México. 2020;85(1):42---47 www.elsevier.es/rgmx REVISTA DE DE MEXICO GASTROENTEROLOGIA ´ ´ ORIGINAL ARTICLE Case-control analysis of fundic gland polyps and proton-pump inhibitors. A pathologist’s perspective  M. Velazquez-Dohorn, C.F. López-Durand, F. Candanedo-González, E.A. Araujo-Villalvazo, A. Gamboa-Domínguez * Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Received 12 October 2018; accepted 6 February 2019 Available online 20 July 2019 KEYWORDS Gastric polyp; PPI; Proton pump inhibitor; Fundic gland polyp; Mexico; Case-control analysis Abstract Introduction and aim: Adequately preserved slides and tissue blocks in pathology archives, when re-reviewed and associated with patient charts, are important tools to further assess prevalence changes and associations of certain pathologies. Our aim was to identify whether proton-pump inhibitor (PPI) use, dose, and duration of use were associated with gastric polyps and their phenotypes in a case-control study. Methods: The slides from patients with a morphologic diagnosis of either hyperplastic polyps or fundic gland polyps were retrieved from the 1980, 1990, 2000, 2010, and 2016 surgical pathology files at a tertiary care hospital in Mexico City and re-evaluated. Cases were paired by age and sex with patients that underwent endoscopy and gastric mucosa biopsy in the same year, with no evidence of polyps. Results: A total of 133 (3.8%) patients with gastric polyps were identified from 3,499 gastric biopsies taken in the abovementioned years and compared with 133 paired controls. Dyspepsia was more prevalent in the controls (p = 0.002) and abdominal pain was more prevalent in the patients with gastric polyps (p = 0.001). PPI use (OR 7.7, 95% confidence interval, 4.4-13.3) and taking more than one PPI medication (OR 4.9, 95% confidence interval, 1.09-22.3) were significantly associated with the presence of gastric polyps. The fundic gland phenotype in the oxyntic mucosa was more frequently associated with PPI use (p < 0.042), with a continuous increase in its prevalence starting in the year 2000 (p = 0.017 for trend). Conclusion: PPI administration for at least one year was associated with gastric fundic gland polyps. © 2019 Asociaci´ on Mexicana de Gastroenterolog´ ıa. Published by Masson Doyma M´ exico S.A. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).  Please cite this article as: Velazquez-Dohorn M, López-Durand CF, Candanedo-González F, Araujo-Villalvazo EA, Gamboa-Domínguez A. Análisis de casos y controles de pólipos de glándulas fúndicas e inhibidores de bomba de protones. La perspectiva de un patólogo. Revista de Gastroenterología de México. 2019. https://doi.org/10.1016/j.rgmx.2019.02.007. * Corresponding author. Departamento de Patología. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Phone: ++ 52 (55) 5487-0900 ext. 7109; 2184. E-mail address: agamboad@gmail.com (A. Gamboa-Domínguez). 2255-534X/© 2019 Asociaci´ on Mexicana de Gastroenterolog´ ıa. Published by Masson Doyma M´ exico S.A. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).