                  SHAHLA KARIM AL ALAF DEMAN IBRAHIM OMER Department of Obstetrics and Gynaecology Hawler Medical University, College of Medicine. Andazyaran Qrt., Majidi St. KURDISTAN REGION, IRAQ Shahla_alaf@yahoo.com Dr_Deman63@yahoo.com   2 Gestational Trophoblasic Diseases (GTDs) are uncommon chorionic tumor of the placenta. It includes a spectrum of diseases from the usually benign hydatidiform mole to the highly malignant choriocarcinoma. A descriptive observational study carried out on 40 cases with GTDs to determine the rate, epidemiological correlates, clinical behavior, and common complications of the disease. The study done on pregnant women admitted to Maternity teaching hospital, Erbil city, North of Iraq, Kurdistan region during the period from 1 st October 2008 to the 1 st of April 2009. Demographic data were collected from each patient, history of prior molar pregnancy, socioeconomic state, presenting symptoms, complete examination and investigation done for all of them. The incidence of GTD was 1 in every 318 pregnant women. The highest incidence was in 40 years old women and more, the mean gestational age was 11± 3.7 weeks, 82.5% of cases were complete mole, 10% were partial mole, and 7.5% were gestational trophoblastic neoplasm. Majority of cases (87.5%) presented with vaginal bleeding, pregnancy induced hypertension and preeclmpsia in 15%of cases, 67.5% had abdominal cramps, 50% presented with hyperemesis gravidarum, 25% had hyperthyroidism. There was a statistically significant association between the Gestational Trophoblastc Neoplasia and the presence of theca lutein cysts and history of molar pregnancy in the antecedent pregnancy. The incidence of GTDs in Maternity teaching hospital (1 in 318) is comparable to the incidence in some Middle East and Far Eastern countries.  2 Gestational trophoblastic diseases, Hydatidiform mole, Gestational trophoblasic neoplasia, Hyper emesis gravidarum, Invasive mole, Choriocarcinoma.   Gestational trophoblastic diseases, characteristically secreting high levels of B2 HCG, are a heterogeneous group of neoplastic conditions arising from the abnormal development of trophoblastic tissues. The spectrum of GTD includes hydatidiform molar pregnancies (partial and complete), choriocarcinoma, and placental site trophoblastic tumor. Occasionally, malignant growth may not become clinically evident until years after the last gestation !" . For reasons not well understood, the incidence of hydatidiform mole (HM) varies greatly in different parts of the world. The highest rates are reported in the Far East where the disease is 7 to 8 times more common than the west !#" . Epidemiological investigation of the incidence and etiology of the Gestational Trophoblastic Diseases (GTD) is receiving increasing attention. The early stages of a pregnancy in which a GTD develops typically seem normal, then symptoms of the pregnancy are exaggerated for example the uterus may grow more rapidly Proceedings of the WSEAS International Conference on ENVIRONMENT, MEDICINE and HEALTH SCIENCES ISSN: 1790-5125 35 ISBN: 978-960-474-170-0