Research Article Early and Ultraearly Administration of Tranexamic Acid in Traumatic Brain Injury: Our 8-Year-Long Clinical Experience Nurdan Acar , 1 Mustafa Emin Canakci , 1 and Ugur Bilge 2 1 Emergency Department, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey 2 Family Medicine Department, School of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey Correspondence should be addressed to Nurdan Acar; nurdanergun@gmail.com Received 25 June 2020; Revised 28 July 2020; Accepted 2 September 2020; Published 18 September 2020 Academic Editor: Mario Ganau Copyright © 2020 Nurdan Acar et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. e most important result of head trauma, which can develop with a blunt or penetrating mechanism, is traumatic brain injury. Tranexamic acid (TXA) can be used safely in multiple trauma. Recent studies showed that TXA can be useful in management of intracerebral hemorrhage, especially in reducing the amount of bleeding. e TXA given in the first 3 hours has been shown to reduce mortality. e aim of our study was to evaluate the effectiveness of tranexamic acid used in patients with traumatic brain injury. Method. Patients with trauma in the emergency room between January 2012 and January 2020 were screened in this retrospective study. e inclusion criteria were being over the age of 18 years, tranexamic acid administration in the emergency department, and traumatic brain injury on brain computerized tomography (CT) and control CT imaging after 6 hours. Results. e number of study patients was 51. e median score of GCS was 12.00 (8.00–15.00). Subdural hemorrhage and subarachnoid hemorrhage were the most common findings on brain CT scans. In the group TXA treatment for less than 1 hour, the arrival MAP was low and the pulse was high (p � 0.022 and p � 0.030, respectively). All the patients were admitted with multiple trauma. None of the 51 patients had thrombotic complications and died due to head injury. Conclusion. TXA appears to be a safe drug with few side effects in the short term in head injuries. According to our experience, it comes to mind earlier in multiple trauma, especially in head trauma with pelvic trauma. 1. Introduction e most important result of head trauma that can occur with blunt or penetrating mechanism is traumatic brain injury (TBI). It has been reported in the literature that there are an average of 1.1 million head trauma applications to emergency departments (ED) each year. It was stated that 21% of these cases required hospitalization and 4% were exitus [1]. In studies conducted, the risk of bleeding due to head trauma was found to be approximately 3-4 times higher in patients over 50 years of age than in those under 30 years old. It has been reported that 15.7% of mild head injuries require hospitalization and 35% of these hospitalizations included patients of65 years and older [2]. Even mild head traumas have been reported to cause mortality and serious morbidity in patients using antiaggregants or anticoagulants [3, 4]. Secondary brain injury from intracranial bleeding, cerebral edema, and increased intracranial pressure is the cause of morbidity and mortality after TBI [4, 5]. e antifibrinolytic agent tranexamic acid (TXA) is commonly given to patients to reduce the need for blood transfusion. TXA reduces the number of patients receiving a blood transfusion by about one-third, reduces the volume of blood transfused by about one unit, and halves the need for further surgery to control bleeding in elective surgical pa- tients [6]. TXA has been shown to reduce mortality in trauma patients with extracranial bleeding. e CRASH-2 trial showed that the administration of TXA within 8 h of injury significantly reduces deaths due to bleeding compared to placebo, with no apparent increase in vascular occlusive events [7]. Studies have shown that tranexamic acid can be used safely in head trauma and in the management of in- tracerebral hemorrhages, especially in reducing the amount Hindawi Emergency Medicine International Volume 2020, Article ID 6593172, 5 pages https://doi.org/10.1155/2020/6593172