Bayoumi M et al. American Journal of Diabetes, Obesity & Metabolism 2018, 4:17-24 1 of 8 Altered Platelets Morphological Parameters in Obese Adults with Type 2 Diabetes Mellitus in Sudan Magdi Bayoumi*, Sheraz Mourtadaa, Sahar Elbager Faculty of Medical Laboratory Sciences (MLS), University of Medical Sciences and Technology (UMST), Sudan Keywords: Obesity; Mean Platelet Volume (MPV); Platelet Distribution Width (PDW); platelet count; type 2 diabetes mellitus; cardiovascular complications Received: July 12, 2018; Accepted: August 4, 2018; Published: August 22, 2018 Competing Interests: The authors have declared that no competing interests exist. Copyright: 2018 Bayoumi M et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. * Correspondence to: Magdi Bayoumi, Faculty of Medical Laboratory Sciences (MLS), University of Medical Sciences and Technology (UMST), Sudan Email: bayoumi.magdi@gmail.com Abstract: Background: Obesity and diabetes are growing global health problems that significantly affect patient quality of life and associated with an increased risk factor for cardiovascular diseases. Accumulating evidence indicates that platelet hyperactivity is a contributing factor to the cardiovascular complications. This study aimed to evaluate the platelet morphological parameters and platelets count in obese type 2 diabetes mellitus in adult patients. Method: A total of 190 subjects, 90 types 2 diabetes mellitus patients without known cardiovascular diseases [60 obese with BMI ≥30 kg/m2 and 30 non-obese] and 100 age and the sex-matched non-diabetic control group included from adults undergoing routine investigation for other problems in the same center. Venous blood samples were collected in EDTA. Platelet counts and Platelet morphological parameters [MPV, PDW] were performed using the Sysmex KN-21N. Results: The mean platelet counts in the diabetic group were higher than in the non-diabetic group, but the difference was not statistically significant (275.7±70 vs. 261.9±59 × 10 9 /L; P > 0.05). The mean MPV was significantly higher in type 2 diabetic group as compared with the non-diabetic group to (9.7 ± 0.4 fl vs. 7.4 ± 0.1 fl; P =000). The mean PDW was significantly higher in Type 2 diabetic group as compared to the non-diabetic group (11.7± 0.4 fl vs 9.3± 0.1 fl P = 0.000). Among the Type 2 diabetic patients, MPV and PDW were significantly higher in Type 2 diabetic obese group as compared with a non-obese group (9.8± 0.5fl vs. 8.4± 0.2 fl; P= 0.000) and (11.8±0.4 vs. 10.4±0.3fl; P= 0.000) respectively. Conclusion: Sudanese type 2 diabetic obese individuals manifest evidence of high platelet reactivity which may further subsequently increase their risk of cardiovascular complications. American Journal of Diabetes, Obesity & Metabolism http://ivyunion.org/index.php/aajdom/index Research Article Ivy Union Publishing | http: //www.ivyunion.org August 22, 2018 | Volume 4 | Issue 1