©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (2): 1392-1398 (2013) The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease S. Simsek 1 , S. Tekes 1 , D. Oral 1 , A. Turkyilmaz 1 , B. Isik², M.R. Isik³ and H. Akkoc 4 ¹Department of Medical Biology and Genetics, Medical Faculty, Dicle University, Diyarbakir, Turkey ²Department of Biochemistry, Medical Faculty, Dicle University, Diyarbakir, Turkey ³Department of Chest Diseases and Tuberculosis, Medical Faculty, Dicle University, Diyarbakir, Turkey 4 Department of Pharmacology, Medical Faculty, Dicle University, Diyarbakir, Turkey Corresponding author: S. Simsek E-mail: seldatsimsek@gmail.com Genet. Mol. Res. 12 (2): 1392-1398 (2013) Received September 13, 2012 Accepted February 15, 2013 Published April 25, 2013 DOI http://dx.doi.org/10.4238/2013.April.25.10 ABSTRACT. An insertion/deletion (I/D) polymorphism was identifed in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoking control individuals were recruited for this study. The distribution of ACE genotypes in these individuals was studied. The frequencies of ACE genotypes were found to be 47.0% for DD, 30.3% for ID, and 22.7% for II in the COPD group and 32.5% for DD, 47.5% for ID, and 20.0% for II in the control group. The allele frequencies were found to be 0.62% for the D allele and 0.38% for the I allele in the COPD group and 0.56% for the D allele and 0.44% for the I allele in the control group. A signifcant difference