Immunome perturbation in arthritic patients who relapse upon withdrawal 1 An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFɑ withdrawal Running title: Immunome perturbation in arthritic patients who relapse upon withdrawal Jing Yao Leong 1 , Phyllis Chen 1 , Joo Guan Yeo 1,2 , Fauziah Ally 1 , Camillus Chua 1 , Sharifah Nur Hazirah 1 , Su Li Poh 1 , Lu Pan 1 , Liyun Lai 1 , Elene Seck Choon Lee 2 , Loshinidevi D/O Thana Bathi 1 , PRCSG 5 , Thaschawee Arkachaisri 1,2 , Daniel J. Lovell 3,4,5 , Salvatore Albani 1 Author affiliations: 1 Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, the Academia, 20 college road, Discovery tower level 8, Singapore 169856. 2 Rheumatology and Immunology Service, KK Women’s and Children’s Hospital 100 Bukit Timah Road, Children’s Tower level 3, Singapore 229899. 3 Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 4 Department of Paediatrics, University of Cincinnati College of Medicine Cincinnati, Ohio, USA. 5 Pediatric Rheumatology Collaborative Study Group (PRCSG). Authors involved in clinical trial are listed in Acknowledgement and affiliations in online supplementary. not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was this version posted May 31, 2019. . https://doi.org/10.1101/656124 doi: bioRxiv preprint