Ivy Union Publishing | http: //www.ivyunion.org ISSN 2572-5734 May 19, 2015 | Volume 3 | Issue 1 Gajjar D et al. American Journal of Polymer Science & Engineering 2014, 3:73-89 Page 1 of 17 Development, Characterization of Hydroxyl Terminated Dendritic Macromolecules as Prospective Drug Carriers Dhaval Gajjar 1 , Devang Wadia 2 , Rajni M. Patel 3 , Pravinkumar M. Patel 1 * 1 Industrial Chemistry Department, V.P. & R.P.T.P. Science College, Affiliated to Sardar Patel University, Vallabh Vidhyanagar, Gujarat, India 2 Analytical Development Laboratory (Formulation), Nirlife Heathcare Division, Nirma Limited, Ahmedabad, India 3 P.D. Patel Institute of Pure and Applied Science, Charusat University, Changa, Gujarat, India American Journal of Polymer Science & Engineering Research Article American Journal of Polymer Science & Engineering http://www.ivyunion.org/index.php/ajpse/index Vol 3, Article ID 201500632, 17 pages Keywords: Triazine based dendrimer; ketoprofen; sustained release; cytotoxicity; hemolysis Academic Editor: Taihong Shi, PhD, PhD, Sun Yat-sen University, China Received: February 24, 2015; Accepted: April 20, 2015; Published: May 19, 2015 Competing Interests: The authors have declared that no competing interests exist. Copyright: 2015 Patel PM et al . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Correspondence to: Pravinkumar M. Patel, Industrial Chemistry Department, V.P. & R.P.T.P. Science College, Affiliated to Sardar Patel University, Vallabh Vidhyanagar-388120, Anand, Gujarat, India Email: drpravinpatel@rediffmail.com Abstract The principal aspiration is to develop triazine dendrimers as potential drug carriers for sustained release. Triazine based dendrimer was synthesized by divergent method evading protection/ deprotection or functional group interconversion. Synthesized dendrimers were characterized by FTIR, 1 H-NMR, 13 C-NMR and ESI-Mass spectrometry. Synthesized full generation dendrimers G1, G2 and G3 were applied as solubility enhancers of hydrophobic drug ketoprofen. Ketoprofen was loaded by G3 dendrimer by inclusion complex method. Sustained release of ketoprofen from ketoprofen loaded dendrimer was studied and compared to of free ketoprofen. Cytotoxicity and hemolytic assay of dendrimer was studied to evaluate toxicity of dendrimer as drug vehicle.