American Journal of Life Sciences 2020; 8(5): 96-101 http://www.sciencepublishinggroup.com/j/ajls doi: 10.11648/j.ajls.20200805.12 ISSN: 2328-5702 (Print); ISSN: 2328-5737 (Online) Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats Ibrahim Maina Hassan 1 , Bashir Saidu 1 , Ja’afaru Abdullahi Ishaq 1 , Ashiru Dahiru 1 , Nafisat Abdulazeez 1 , Halima Ibrahim Yusuf 1 , Jubril Saidu Fatima 1 , Yushau Shuaibu Baraya 2 , Adamu Abdul Abubakar 3 , Adama Musa Abdullahi 4 1 Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria 2 Department of Veterinary Pathology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria 3 Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria 4 Department of Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria Email address: To cite this article: Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, Halima Ibrahim Yusuf, Jubril Saidu Fatima, Yushau Shuaibu Baraya, Adamu Abdul Abubakar, Adama Musa Abdullahi. Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats. American Journal of Life Sciences. Vol. 8, No. 5, 2020, pp. 96-101. doi: 10.11648/j.ajls.20200805.12 Received: April 2, 2020; Accepted: May 18, 2020; Published: August 27, 2020 Abstract: Medicinal plants have been used in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The global market value of medicinal plant products exceeds $100 billion per annum. This study was conducted to know the effect of Moringa oleifera leaf on Serum biochemistry of experimental exposed Wister rats. Moringa oleifera leaf was extracted with distilled water and concentrated to semisolid form with rotary evaporator at 42°C. Twenty apparently healthy rats weighing 128-233g were exposed to different concentration of Moringa oleifera aqueous leaf extract. Control group were exposed to only distill water. The animals were divided into 3 groups of five rats each, with Group-I exposed to 500 mg/kg crude extract. Group-II exposed to 1000 mg/kg crude extract and Group-III exposed to 2000 mg/kg crude extract. There significant difference (p< 0.05) in analyzed serum biochemical parameters (Creatinine, Urea, Aspartate amino transferase and Alanine amino transferase) between the experimental and control group. From this finding, it can be concluded that Moringa oleifera leaf extract up to 2000mg/kg is safe and cause slight changes in serum biochemistry. Toxicity studies of this plant extracts as well as phytochemical studies to reaffirm it effect in several body tissues and organs and identify the bioactive compounds are highly recommended. Keywords: Alanine Amino Transferase, Aqueous, Aspartate Amino Transferase, Concentration, Creatinine, Moringa oleifera, Urea 1. Introduction Moringa oleifera Lamarack is a species of the genus Moringa belonging to the family Moringacea, it is an important food commodity which has had enormous attention as the ‘natural nutrients in tropics [1]. In many countries, particularly India, Pakistan, Philippines, Hawaii and many parts of Africa the leaf, fruit, flowers and immature pods of this tree are used as vegetable due to it highly nutritive value. Supplementation with Moringa seeds, leaf or their extract has several health benefits as reported [2]. Moringa root, wood lower the deposition of stone forming constituents in the kidneys of calculogenic rats and reduced the elevated urinary oxalate as a result of ethylene glycol treatment [3]. Moringa ameliorated liver fibrosis in rats, reduces liver damage, reverse the symptoms of liver fibrosis as well as decreased the CCl 4 - induced elevation of serum aminotransferase activities and globulin level. Its also reduced the elevated hepatic