Published by Advance Educational Institute and Research Centre International Journal of Endorsing HEALTH SCIENCE RESEARCH Original Article Assessment of the association of ABO blood group in dengue fever diagnosed patient in tertiary care hospital. Shaheen Kouser 1 , Farah Fatima Abbas 2 , Fouzia Naeem Effendi 3 , Nasrul Huda 4 , Munazza Suharwardy Obaid 5 , Humaira Aman Ali 6 , Muhammad Imran 7 , Aabiya Abdus Salam 7 , Alifya Murtaza Ali 7 , Mahrukh Nazneen Suri 7 & Syeda Fatima Munir 7 1 Department of Dr. Ishrat ul Ebad Khan Institute of Blood Diseases, Dow University of Health Sciences, Karachi-Pakistan. 2 Department of Pathology, Dow University of Health Sciences, Karachi-Pakistan. 3 Department of Community Health Sciences, Bahria University Medical & Dental College, Karachi-Pakistan. 4 Department of Anatomy, Dow University of Health Sciences, Karachi-Pakistan. 5 Department of Community Medicine, Dow University of Health Sciences, Karachi-Pakistan. 6 Department of Biochemistry, Dow University of Health Sciences, Karachi-Pakistan. 7 Department of Medical Technology, Dow University of Health Sciences, Karachi-Pakistan. Abstract Background: A serious worldwide medical and public health concern occurs with the dengue virus, which is also an emerging health threat. A victim can be vulnerable and acquire dengue because of his age, genetics, nutritional status, viral strain and secondary infections. Our objective was to identify the ABO blood group system's distribution and relationship in dengue fever (DF) patients. Methodology: The current study was conducted at Dr. Ishrat ul Ebad Institute of Blood Diseases Department between September 2019 and September 2020. The research work was viewed and accepted by the ethics and research committees. Case records of patients with blood systems and their relation among dengue nonstructural protein 1 (NS1) antigen /dengue immunoglobulin M (IgM) and immunoglobulin G (lgG) were included in this study. Results: Among 204 cases, 82 were blood group O positive, 59 were B positive, 38 were A positive, 16 were AB positive, 4 were O negative, and 2 were blood group A negative. The association of the ABO blood group with dengue was statistically significant (p=0.046). Blood group O+ has the highest number of cases, 66 (42.9%), than controls, 16 (32%). Conclusion: This study overall consummates that blood group O is linked with a greater possibility of acquiring DF in comparison with different other blood group types. There is a significant relationship between blood group and DF observed. Keywords Dengue Fever, ABO Blood Group, Immunoglobulin M (IgM), Immunoglobulin G (IgG). Doi: 10.29052/IJEHSR.v9.i1.2021.21-27 Corresponding Author Email: farah.fatima@duhs.edu.pk Received 24/08/2020 Accepted 12/11/2020 First Published 30/12/2020 © The Author(s). 2021 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)