Quest Journals Journal of Medical and Dental Science Research Volume 8~ Issue 12 (2021) pp: 33-38 ISSN(Online) : 2394-076X ISSN (Print):2394-0751 www.questjournals.org *Corresponding Author: - Dr Rajesh Kumar Pandey 33 | Page Research Paper Observational study to monitoring and assessment of Cardiovascular Drugs polypharmacy leading to detect and intercept adverse drug reaction and medication errors 1. Dr Sachida Nand Sachit, Tutor, Dept. of Pharmacology,DMCH,Darbhanga 2. Dr Asha Kumari,Assistant Professor, Dept. of Pharmacology,DMCH,Darbhanga 3. Dr Rajesh Kumar Pandey,Assistant Professor, Dept. of Pharmacology,DMCH,Darbhanga 4. Dr V K Mishra, Professor, Dept. of Pharmacology,DMCH,Darbhanga Corresponding Author- Dr Rajesh Kumar Pandey,Assistant Professor,Dept. of Pharmacology, DMCH, Darbhanga Abstract Objective: The main objective of the study study was to monitoring and assessment of Cardiovascular Drugs polypharmacy leading to detect and intercept adverse drug reaction and medication errors. Materials and Methods: This was a retrospective observational study carried out in a selected departments of a tertiary care hospital. This study was included hospital in and outdoor patients who were treated for cardiovascular disease. Inclusion criteria of the study was either gender who were hospitalized and prescribed with at least one cardiovascular drug. Results: A total 530 patients were enrolled in the current study. 3.4% was found to be he overall incidence of ADR. A higher number of ADRs (n=123) were observed in older patients (≥ 60 years) in contrast with other age groups. male preponderance over female (25% vs. 22%) was observed but the difference was not statistically significant (p = 0.281). 90.9% patients among overall populations were on more that 6 drugs. Only 3.8% patients were on less than 6 drugs. Beta- blockers (14.68%), on evaluation of drug class implicated in ADRs followed by Renin-Aldosterone-Angiotensen-Receptors (RAAS) blockers and anti–coagulants. In the study, management of ADRs showed that out of total ADRs, 56% ADRs were managed by withdrawing suspected drug, 28% ADRs were managed by adding a supplement, 22% ADRs were managed by replacing a drug, 4% ADRs were managed by altering the dose while no change was made in 4% ADRs. 72% were the possible causality parameters while 53% were having mild severity with 85% were not preventable. Conclusion: In preventing polypharmacy and medication related problems like ADR, building awareness for spontaneous reporting of adverse drug reaction to healthcare professionals and following the evidence based medicine (EBM). To prevent further recurrence, high incidence of ADRs insists for vigilant monitoring. The reporting and monitoring aspects of ADRs might improved by intervention by clinical pharmacists. Keywords: Adverse drug reaction, Cardiovascular drugs, Poly pharmacy, Assessment, Monitoring and Outcomes. Received 08 Dec, 2021; Revised 21 Dec, 2021; Accepted 23 Dec, 2021 © The author(s) 2021. Published with open access at www.questjournals.org I. Introduction: Adverse reactions to drugs increases significantly by poly-pharmacy along with medication error or risk of hospitalization related to drugs. Is depend on the patient related factors, the disease and the number of drugs. Increased risk of mortality is associated with severe adverse drug reactions (ADRs) caused by polypharmacy [1]. Adverse drug ration, drug interaction, increased risk of side effects, poor compliance and increased costs are few negative connotations carries by poly-pharmacy [2]. Adverse drug reaction (ADR) defines by the World Health Organization (WHO) as “any response to a drug which is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of a disease, or for the modification of physiological function”. Type-A (Augmen-ted) and Type-B (Bizzare) reactions are major two traditional classification of ADR’s [3]. in recent time’s clinical interventions one of the most common is poly-pharmacy and concomitant use of