This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/JTH.14972 This article is protected by copyright. All rights reserved DR ERICA SPARKENBAUGH (Orcid ID : 0000-0002-5529-7847) DR NIGEL KEY (Orcid ID : 0000-0002-8930-4304) Article type : Original Article High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease. Erica M Sparkenbaugh 1 , Malgorzata Kasztan 2 , Michael W Henderson 1 , Patrick Ellsworth 1 , Parker Ross Davis 2 , Kathryn J Wilson 1 , Brandi Reeves 1 , Nigel S Key 1,5 , Sidney Strickland 3 , Keith McCrae 4 , David M. Pollock 2 , Rafal Pawlinski 1* 1 UNC Blood Research Center, Division of Hematology & Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; 2 Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL; 3 Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY; 4 Taussig Cancer Institute, Department of Hematology Oncology, Cleveland Clinic, Cleveland, OH; and 5 Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC. *Address for correspondence Rafal Pawlinski 8008B Mary Ellen Jones Bldg, CB 7035 Accepted Article