10.22376/ijpbs/lpr.2020.10.5.P11-16 ijlpr 2020; doi Revised On 26 June 2020 Accepted On 05 August 2020 Published On 07 December 2020 Funding This research did not receive any specific grant from any funding agencies in the public, commercial or not for profit sectors. Copyright @ International Journal of Life Science and Pharma Research, available at www.ijlpr.com Int J Life Sci Pharma Res., Volume11., No 5 (December) 2020, pp P11-16 This article is under the CC BY- NC-ND Licence (https://creativecommons.org/licenses/by-nc-nd/4.0) Citation Ramyasree Jwalapuram, Hindustan Abdul Ahad, Chinthaguinjala Haranath, Reshma Thadipatri, Chenga Venkata Hima Varshitha, Yedire Bharath Kumar , A desktop reference to the solubility enhancement of drugs with the aid of surfactants..(2020).Int. J. Life Sci. Pharma Res.11(5), P11-16 http://dx.doi.org/10.22376/ijpbs/lpr.2020.10.5.P11-16 Recieved On 15 May 2020 Hindustan Abdul Ahad , Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu 515721, AP, India *Corresponding Author Review Article Pharmaceutics for novel drug Formulations International Journal of Lifescience and Pharma Research Solubility Enhancement of Drugs with Aid of Surfactants: Research Done Since Last Two Decades Ramyasree Jwalapuram 1 , Hindustan Abdul Ahad 2* , Chinthaguinjala Haranath 2 , Reshma Thadipatri 1 , Chenga Venkata Hima Varshitha 1 and Yedire Bharath Kumar 3 1 Department of Quality Assurance, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu 515721, AP, India 2 Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu 515721, AP, India 3 Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Ananthapuramu 515721, AP, India Abstract: This review aims to explore the past work done on the solubility enhancement of drugs using surfactants. Surfactants plays an important part in many routes of interest in both essential and practical science. The most vital function of surfactant is the formation of micelle in solution, which has specific significance in medicine because of their ability to improve the solubility of poorly water-soluble drugs, which need high doses to extend therapeutic plasma levels after oral administration. Poor water solubility is the major issue met with the formulation development of new chemical objects. A drug taken by the patient should present in the solution form at the site of absorption. The use of surfactants to elevate the dissolution of poorly soluble drugs has been employed. Surfactants can reduce surface tension and improve the dissolution of lipophilic drugs in the aqueous medium. When the levels of surfactants surpass their critical micelle concentration it deceives the drugs within the micelles. The authors collected sufficient literature on work done on the solubility enhancement of drugs using surfactants and presented in this paper. The authors conclude that this quick reference will be helpful for researchers in finding the literature on solubility enhancement of drugs using surfactants on a single click. Keywords: Surfactants, solubility, absorption, drugs, literature, P-11