ISSN(Online): 2319 - 8753 ISSN (Print) :2347 - 6710 International Journal of Innovative Research in Science, Engineering and Technology (An ISO 3297: 2007 Certified Organization) Vol. 4, Issue 5, May 2015 Copyright to IJIRSET DOI: 10.15680/IJIRSET.2015.04050108 3525 Synthesis and Biological Evaluation of New 2-(5-fluoro-2-methyl-lH-inden-3-yl) Acetohydrazide Derivatives R. B. Kawde 1 , D. V. Patil 2 , J. K. Patil 3 and V. D. Jadhav 4 Associate Professor, Department of Chemistry, Kirti M. Doongursee College, Dadar (W), Mumbai, India 1 Assistant Professor, Department of Chemistry, Kirti M. Doongursee College, Dadar (W), Mumbai, India 2 Research Scholar, Department of Chemistry, Kirti M. Doongursee College, Dadar (W), Mumbai, India 3 Research Scholar, Department of Chemistry, Kirti M. Doongursee College, Dadar (W), Mumbai, India 4 ABSTRACT: Compound 2-(5-fluoro-2-methyl-1H-inden-3-yl) acetohydrazide was reacted with various substituted aldehydes at elevated temperature in methanol to yield substituted N-benzylidene-2-(2-methyl-1H-inden-3-yl) acetohydrazide as sole product. It is also observed that reaction went to completion during 8-10 hrs at reflux condition without adding any acid or base catalyst. The reaction condition found general for all the substituted benzaldehyde. These derivatives are found more than 80% in yield. These new compounds are studied for the antimicrobial activity. KEYWORDS: Acetohydrazide, methanol , antimicrobial activity. I. INTRODUCTION The literature survey shows the utility of indene-acetic acid compounds as the pharmaceutical as well as fungicide and herbicide activity 1 . The Fluorinated organic molecules are familiar for a wide range of biological functions 2-4 . In the present paper the imino derivatives of hydrazide of 5-fluoro-2-methyl indene-3-acetic acid are prepared and studied for the biological evaluation. Acetohydrazides show anti-tuberculosis activity 5 . This Information provoked us to synthesise fluorine substituted Indene-3-aceticacid and its relative derivatives which could possibly show enhanced biological activity. Due to its versatile nature work was initiated from compound-1 which is the key raw material of Sulindac. O OH F Compound-1 II. MATERIALS AND METHODS A. R. grade or purified L. R. grade chemicals were used for the synthesis of 2-(5-fluoro-2- m e t h yl - 1 H- inden-3-yl)acetohydrazide. Synthesis of Methyl-5-fluoro-2-methyl-1H-3-indenylacetate: The esterification of 2-(5-fluoro-2-methyl-1H-inden-3- yl) acetic acid (1) was carried out by refluxing compound-1 in excess of methanol in presence of the catalytic amount of sulphuric acid to form compound-2. O O F F O NH NH 2 Compound-2 Compound-3