Kaushik et al Journal of Drug Delivery & Therapeutics. 2017; 7(3):117-126 ISSN: 2250-1177 [117] CODEN (USA): JDDTAO Available online on 10.06.2017 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open access to Pharmaceutical and Medical research © 2011-17, publisher and licensee JDDT, This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited Research Article SOLUBLITY ENHANCEMENT OF MICONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS Anu Kaushik*, Rakesh Kumar Jat Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University Jhunjhunu Rajasthan, 313001, India ABSTRACT In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting points determination. Sodium benzoate, niacinamide and urea are the hydrotropes were selected for the solubility enhancement of drugs Solubility enhancement ratios for selected poorly water-soluble drugs were determined. Results showed that remarkable increase in aqueous solubility of Miconazole in presence of large concentration of hydrotropes. Marketed Miconazole tablets determined by spectrophotometric analysis using hydrotropic solubilization techniques. Validation of the proposed analysis methods is confirmed by satisfactorily low values of statistical parameters viz., standard deviation, percent coefficient of variation and standard error. Keywords: Solubility enhancement, hydrotropes, Solid dispersion, Miconazole. Article Info: Received 05 May, 2017; Review Completed 09 June, 2017; Accepted 09 June, 2017; Available online 10 June, 2017 Cite this article as: Kaushik Anu, Jat RK, Solubility enhancement of miconazole by formulation of hydrotropic solid dispersions, Journal of Drug Delivery and Therapeutics. 2017; 7(3):117-126 DOI: http://dx.doi.org/10.22270/jddt.v7i3.1459 *Address for Correspondence Institute of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University Jhunjhunu Rajasthan, 313001, India Email: anu171417@gmail.com INTRODUCTION In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water soluble drug (Miconazole). The solubility of drugs of pharmaceutical formulation in water is very great problem of present day. There are so many techniques or methods are used nowadays to increase the solubility of different pharmaceutical preparations 1 . Use of Solid dispersion 2,3 , cyclodextrin 4 and polysaccharide chitosans 5 , dendrimers 6 , preparation of buffers, Liquisolid techniques 7 , complex formation, chelation and salting in are different procedures to increase the solubility of active constituents. Different solubilization techniques have various advantage and disadvantage in the formulations. Hydrotropic solubilization is one of the techniques that are used to increase aqueous solubility of different dosages forms in pharmaceutical industry. In hydrotropic solubilization a large amount of hydrotropic agents like urea, sodium benzoate, sodium citrate, sodium salicylate, sodium alginate, nicotinamide, glycine etc are used in parts by agitating the solution vigorously adding agents after regular intervals. The hydrotropes forms agglomerates with drugs to dissolve and salting in phenomena takes place in the mechanism. The hydrotropes are eco-friendly, cheap and harmless to the preparations as compared to organic solvents such as chloroform, methanol, petroleum ether etc. that are toxic to environment, very costly, inflammable and evaporable. The organic solvents are hazardous to environment as compared to hydrotropes. Mixed hydrotropic solubilization is now more advanced version of hydrotropic solubilization. In this technique two or more hydrotropes are taken in different ratios to increase the solubility of the drug. Itself pharmaceutical ingredient also acts as hydrotropes to increase the solubility of other drugs. The hydrotropes form agglomerates and increase the solubility of different pharmaceutical formulations by salting in mechanism. From literature survey, it is evident that urea has been extensively employed to make solid dispersions of a large number of poorly water-soluble drugs (by fusion or common solvent technologies). As evident from solubility studies, urea has been found to enhance aqueous solubility of Miconazole significantly. Therefore, this poorly water-soluble drugs and urea as a model hydrotropic agent selected to prepare hydrotropic solid dispersions for solubility enhancement study. The prepared solid dispersions have been characterized by DSC, XRD and IR studies. They have