Case Study International Journal of Research - GRANTHAALAYAH ISSN (Online): 2350-0530 May 2021 9(5), 24–29 ISSN (Print): 2394-3629 Received 18 April 2021 Accepted 4 May 2021 Published 31 May 2021 Corresponding Author Ayse KONAC, ayse.konac1@gmail. com DOI 10.29121/ granthaalayah.v9.i5.2021.3899 Funding: This research received no speciϐic grant from any funding agency in the public, commercial, or not-for-proϐit sectors. Copyright: © 2021 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ANENCEPHALIC FETUS WITH CRANIOSPINAL RACHISCHISIS – CASE REPORT Ayse KONAC 1 1 Gelisim University Health Sciences, Istanbul, Turkey ABSTRACT Anencephaly, in which a substantial part of the brain, skull, or scalp is miss- ing, is a lethal neural tube defect (NTD) that occurs during the fourth week of pregnancy after failed cranial neuropore closure. One in every 1,000 births is anencephalic, and newborns with this NTD are not viable or treatable. Associ- ated with anencephaly is rachischisis, or severe incomplete neural tube closure and exposure of the spinal cord. Ultrasonography can quickly diagnose anen- cephaly. Like other NTDs, nutritional and environmental factors both play a role in the development of anencephaly. Here, we report and discuss an unusual case of a 12-week gestation anencephalic fetus with craniospinal rachischisis and its embryological roots. In our case, except from the low socio-economic life of the patient, the absence of a predisposing factor that could cause such an anomaly, the abor- tion being in the ϐirst trimester and the occurrence in the ϐirst pregnancy of the patient as a result of 5-year infertility made us think that pathology examination of the abortus material is important in complet or incomplete abortions. Keywords: Anencephaly, Neural Tube Defect, Rachischisis, İncomplet Abortion, First Trimester 1. INTRODUCTİON Anencephaly is a lethal congenital neural tube defect (NTD) that occurs in 1 in every 1,000 births. It is the most prevalent anomaly that affects the central nervous sys- tem like other NTDs, anencephaly affects neural and non-neural tissues, including vertebrae, muscles, and skin Gupta (2004); Salder and Lagman’s (2012). The Genesis of Anencephaly is directly related to neur like other NTDs (e.g., Spina Biϐida, Encephalocele, Cranioracalvaria), Anencephaly affects neural and non-neural tissues, including vertebrae, muscles, and skinulation, or the process in which the and neurulation is the process in which the neural plate, a neuroectoderm derivative, forms a neural tube that produces the primitive CNS. The lateral edges of the neural How to cite this article (APA): KONAC, A. (2021). Anencephalic fetus with craniospinal rachischisis – case report. International Journal of Research - GRANTHAALAYAH, 9(5), 24-29. doi: 10.7821/granthaalayah.v9.i5.2021.3899 24