Impact Factor: ISRA (India) = 1.344 ISI (Dubai, UAE) = 0.829 GIF (Australia) = 0.564 JIF = 1.500 SIS (USA) = 0.912 РИНЦ (Russia) = 0.179 ESJI (KZ) = 1.042 SJIF (Morocco) = 2.031 ICV (Poland) = 6.630 PIF (India) = 1.940 ISPC Technological advances, Lancaster, USA 59 SOI: 1.1/TAS DOI: 10.15863/TAS International Scientific Journal Theoretical & Applied Science p-ISSN: 2308-4944 (print) e-ISSN: 2409-0085 (online) Year: 2015 Issue: 11 Volume: 31 Published: 30.11.2015 http://T-Science.org Mohiniso Bahromovna Hidirova PhD, Senior Scientist, dept.”Regulatorika” Centre for the development of software and hardware program complexes at Tashkent University of Informational Technologies, Tashkent, Uzbekistan regulatorika@yahoo.com Zaynabhon Djumanazarovna Yusupova Senior teacher of dept. “System and applied programming” Tashkent University of Informational Technologies Tashkent, Uzbekistan zaynabhon@inbox.ru SECTION 2. Applied mathematics. Mathematical modeling. ANALYSIS MECHANISMS OF CARDIAC TISSUE EXCITEMENT TAKING INTO ACCOUNT DELAY IN REGULATION SYSTEM Abstract: Increasing interest in quantitative studies of mechanisms of cardiac tissue excitements is stipulated by the absence of generally accepted models for origin and developments of many cardiac diseases, including arrhythmia and sudden cardiac death. In the article the differential equations of cardiac cellular systems excitement with taking into account temporary relations in regulation system of cardiac activity are considered. Key words: excitation of the cardiac tissue, differential-difference equation, modeling of regulatory mechanisms of the heart, delay time. Language: English Citation: Hidirova MB, Yusupova ZD (2015) ANALYSIS MECHANISMS OF CARDIAC TISSUE EXCITEMENT TAKING INTO ACCOUNT DELAY IN REGULATION SYSTEM. ISJ Theoretical & Applied Science 11 (31): 59-62. Soi: http://s-o-i.org/1.1/TAS-11-31-10 Doi: http://dx.doi.org/10.15863/TAS.2015.11.31.10 It is considered that the cardiovascular system is a major integrative, that is central, in terms of life support the body. Cardiovascular diseases currently represent a serious problem for human health. Therefore it is required to study the mechanisms of functioning of the heart as a whole. There is a sufficient number of techniques, allowing versatile study the state of the heart. So today, a number of software and hardware systems, allows us to observe the reconstruction of the anatomical structure of the atria and visualize the dynamics of excitation: CARTO BiosenseWebster (USA); EnSite Endocardial Solutions (USA); Bhotok3D Scientific and Production Association (Tomsk); Elcart Navigator II IPC "Electropulse (Tomsk). Graphic course of the pulse excitation of the heart muscle allows us to understand the mechanisms of arrhythmias and the possibility of predestination possible changes after exposure. These models have the ability to visualize the essence of the excitation dynamics. However, they do not have adequate predictive function evaluation. Nevertheless, in certain situations, only one imaging is extremely insufficient. Current research on modeling the dynamics of excitation (the heart as a whole, and individual departments) focused on research or the heart as an object of study, or simulation of the properties of the active medium with separate its characteristic effects. In clinical practice, these techniques are not widely used due to their complexity. Also, due to the high cost of building expensive individual model. And the possibility of using ready-made templates making impossible due to the uniqueness of each of them. In this regard, the study of the regulatory mechanisms of the heart with the help of mathematical modeling is very important [1-5]. O.I. Adebisi, I.A.Adejumobi, I.O. Abiala and S.O. Omotainse [6] tried to create a mathematical model of cardiac electrical activity, in order to understand the different mechanisms of the heart and abnormal heart condition. The electrical activity of the cardiac heart tissue, presented in this paper was based on a coupling consideration bidomain model and the ionic model FitzHugh-Nagumo [7], taking into account the closed boundary conditions between the intracellular and extracellular domains to give a complete description of the propagation of electrical waves through the heart tissue. The complete system of differential equations describing the cardiac function of the form [7]: