Research Article Open Access Volume 5 • Issue 6 • 1000279 Med Aromat Plants (Los Angel), an open access journal ISSN: 2167-0412 Open Access Commentary Rajput et al., Med Aromat Plants (Los Angel) 2016, 5:6 DOI: 10.4172/2167-0412.1000279 *Corresponding author: Ratnamala S Bendre, School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India, Tel: +919422211435/+912572257435; E-mail: bendrers@gmail.com Received February 07, 2016; Accepted December 16, 2016; Published December 20, 2016 Citation: Rajput JD, Bagul SD, Tadavi S, Bendre RS (2016) Comparative Anti- Proliferative Studies of Natural Phenolic Monoterpenoids on Human Malignant Tumour Cells. Med Aromat Plants (Los Angel) 5: 279. doi: 10.4172/2167- 0412.1000279 Copyright: © 2016 Rajput JD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Keywords: SRB; Carvacrol thymol; Eugenol; MCF-7: SK-MEL-2; HCT-15; MIAPaCa-2 Introduction Cancer is a serious chronic disease that arises due to changes in many physiological processes in body [1,2]. In general, symbols of cancer were found to be sustaining proliferative signalling, avoiding growth suppressors, control cell death, enabling replicative immortality, inducing angiogenesis, and activating incursion and metastasis, along with two emerging symbols including reprogramming energy metabolism and absconding immune damage [3-5]. Te search for novel small molecules as drugs is still a priority goal for cancer therapy, due to the rapid development of resistance to chemotherapeutic drugs [6]. In addition, the high toxicity usually associated with some bulky anticancer drugs and their undesirable side-efects increase the demand for novel anti-tumour drugs active towards untreatable tumours [7,8] Natural products have long been a substantial source of treatment for melanoma, which is projected to become the main causes of death in this century [9,10]. Te research of last 40 years demonstrated that more than one thousand plants possess signifcant anticancer properties [11]. while many molecules obtained from these plants have shown wonderful anticancer properties [12,13]. Some of them showed efective delivery in biological system to reduce the action of cancer disease, without toxic and other side efects against healthy cells and tissues [14]. Carvacrol (1), thymol (2) and eugenol (3) are part of a naturally occurring class of compounds known as phenols [15]. Tey are well-known naturally occurring phenolic monoterpenoids found primarily in oils of oregano, thyme, and marjoram, and are recognized as traditional therapeutic agents [16,17]. All the major groups of angiosperms biosynthesize these biocides [18]. Currently, these biocides are used in food favouring ingredients and preservatives, as well as a fragrance ingredients in cosmetic formulations [19]. In recent years, signifcant research has been undertaken as an efort to establish the biological actions of these phenolic monoterpenoids for their potential use in pharmaceutical and agricultural applications [20]. Some results from in-vitro and in-vivo studies showed that carvacrol, Comparative Anti-Proliferative Studies of Natural Phenolic Monoterpenoids on Human Malignant Tumour Cells Jamatsing D Rajput, Suresh D Bagul, Samina Tadavi and Ratnamala S Bendre* School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, India Abstract In present study we report prominent effect of carvacrol (5-isopropyl-2-methyl phenol), thymol (2-isopropyl-5- methyl phenol) and eugenol (4 allyl-2-methoxyphenol) on Human melanoma cells. These three compounds were screened for Anti-proliferative test by using Sulforhodamine B (SRB) assay. For this investigation we used human breast melanoma cell line MCF-7, human skin melanoma cell line SK-MEL-2, human colon melanoma cell line HCT-15 and human pancreatic melanoma cell line MIAPaCa-2. Carvacrol was identifed as most potent molecule with low GI 50 value as 0.1 μL for selected human cancer cell lines; which is comparatively equal to standard drug 14 Adriamycin (ADR). Thymol and Eugenol also exhibited remarkable GI 50 for human cancer cell 15 lines. M e d i c i n a l & A r o m a t i c P l a n t s ISSN: 2167-0412 Medicinal & Aromatic Plants