~ 1 ~ International Journal of Unani and Integrative Medicine 2017; 1(1): 01-04 E-ISSN: 2616-4558 P-ISSN: 2616-454X IJUIM 2017; 1(1): 01-04 Received: 01-05-2017 Accepted: 02-06-2017 Mohd. Aleemuddin Quamri Reader, Department of Moalajat, National Institute of Unani Medicine, Bangalore, Karnataka, India Shabana Begum PG Scholar, Department of Moalajat, National Institute of Unani Medicine, Bangalore, Karnataka, India MA Siddiqui HoD, of Moalajat & Director National Institute of Unani Medicine, Bangalore, Karnataka, India Md. Anzar Alam PhD Scholar, Department of Moalajat, National Institute of Unani Medicine, Bangalore, Karnataka, India Correspondence Mohd. Aleemuddin Quamri Reader, Department of Moalajat, National Institute of Unani Medicine, Bangalore, Karnataka, India Efficacy of Kanduri (Coccinia indica) in diabetes associated dyslipidemia - A randomized single blind standard controlled study Mohd. Aleemuddin Quamri, Shabana Begum, MA Siddiqui and Md. Anzar Alam Abstract Background and objectives: Diabetes mellitus is characterized by elevated blood glucose, it can leads to serious vascular complications with poor prognosis. Dyslipidemia secondary to DM is one of the aggravating risk factor for cardiovascular diseases. In Unani system of medicine Diabetes associated Dyslipidemia has been treating with several potent anti-hyperglycemic and anti-dyslipidemic single drugs. To evaluate the effect of Kanduri (Coccinia indica) among patients of Dyslipidemia associated with type II Diabetes mellitus this study is conducted. Methods: A single blind, randomized, standard control clinical trial on patients of Dyslipidemia secondary to Diabetes Mellitus Type II was conducted by randomly allocating the patients into two groups viz test (n=20) and control group (n=20) for a period of 8 weeks. Test group received 7.5 gram powder of dried leaves of Kanduri and control group received Tablet Metformin SR 500 mg. Both groups recieved drugs twice a day orally before meals.The study outcome was assessed with the difference in the objective findings of pre and post treatment. Results: Objective parameters like TC, TGL, LDL, HDL were found insignificant, applying tests were paired t test, Wilcoxon matched pair test and Friedman test for intra group comparison and one way ANOVA and Kruskal- Wallis test with Dunn’s multiple pair comparison for inter group comparison with p>0.05. Interpretation & Conclusion: This comparative trial revealed that interventions of both groups have no effect on Dyslipidemia associated with DM type II, however, the both the drugs were found to be free from any adverse effects. Keywords: Diabetes associated dyslipidemia, Kanduri, Coccinia Indica Introduction Dyslipidemia is one of the major risk factor for cardiovascular disease in Diabetes [1] . It is well-established that dyslipidemia is a major risk factor for macrovascular complications in patients with type-2 diabetes mellitus (T2DM) and affects 10%-73% of this population [2, 3] . The characteristic features of diabetic dyslipidemia are high plasma triglyceride concentration, reduced high density lipoprotein cholesterol (HDL-c) concentration, and increased concentration of small dense LDL particles [4] . Early detection and treatment of dyslipidemia in type-2 diabetes mellitus can prevent risk for atherogenic cardiovascular disorder [5] . Metformin treatment improves weight and dyslipidemia in children with metabolic syndrome [6] . In Unani system of medicine various single and compound drugs have been described for the treatment of dyslipidemia and diabetes [7, 8] . Some of the herbs like Luk (Laccifer lacca), Zeera (Carum carvi), Gurmar Booti (Gymnema Sylvester), Tukhm Jayat (Withania coagulans), Post Kachnal (Bauhinia varigata), Darhald (Berberis aristata), Tukhm Methi (Trigonella foenum graecum ), Kanduri (Coccinia indica ), Tahlab (Spirulina maxima) etc have been scientifically reported to have potent effects properties like as antioxidant, immunomodulator, antidiabetic, and antidyslipidaemic [9, 10] . Kanduri (Coccinia indica) is a climbing herb belongs to the family of Cucurbitacae (Figures 1 and 2) [11] . Major chemical constituents of kanduri are alkaloids, carbohydrate, proteins amino acids, tannins, saponins, flavonoids, phytosterol, triterpenes, Heptacosane, cephalandrol, alkaloids. Cephalandrine A and B [12] . It showed significant triglycerides and cholesterol lowering effects among Dyslipidemic patients [13-17] . The reason behind preferring Metformin SR as a standard control is of great importance because it shares similar actions as the trial drug such as hypoglycemic, cardioprotective, nephroprotective, anti-dyslipidemic effect etc. [18, 19] .