SJM (2021) 24 Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients Mahvira Chow Liana Herman Adil 1 , Nopriyati Nopriyati 2 , Desi Oktariana 3* , Yuli Kurniawati 2 , Gita Dwi Prasasty 4 1 Medical Education Study Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia 2 Departement of Dermatology and Venereology, Dr. Mohammad Hoesin Hospital, Palembang, Indonesia 3 Departement of Clinical Pathology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia 4 Departement of Parasitology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia E-mail: desioktariana@fk.unsri.ac.id Abstract Several studies regarding the quality of life of chronic spontaneous urticaria patients based on Autologous Serum Skin Test (ASST) results have shown a variety of results. This study aims to determine the correlation between the quality of life and ASST results in chronic spontaneous urticaria patients at Dermatology and Venereology (DV) Outpatient Clinic of Dr. Mohammad Hoesin Hospital Palembang. This analytic observational study with a cross-sectional design used secondary data in the form of medical records. 76 samples met the inclusion criteria from 110 samples of chronic spontaneous urticaria patients at DV outpatient clinic. The distribution of chronic spontaneous urticaria patients was highest in the 17-25 year age group (23.7%) and the female group (64.5%). The majority of chronic spontaneous urticaria patients had negative ASST results (52.6%). The effect of chronic spontaneous urticaria on the decline in quality of life was mostly moderate (35.5%). The bivariate analysis between DLQI score and ASST results with a value of p = 0.307 or p> 0.05 showed no significant correlation between the quality of life and ASST results. Keywords: Autologous Serum Skin Test, Chronic Spontaneous Urticaria, Quality of Life ________________________________________________________________________________________________ 1. Introduction Urticaria is a vascular reaction of the skin in the form of local edema (wheal) surrounded by a red halo (flare) and accompanied by itching, stinging, or a stabbing sensation. Urticaria that lasts less than 6 weeks is called acute urticaria, urticaria that lasts 6 weeks or more with attacks that occur at least 2 times a week is called chronic urticaria. 1 Unlike acute urticaria whose cause is known, the cause of chronic urticaria is unknown in most cases. 2 Chronic urticaria is divided into chronic physical urticaria and chronic spontaneous urticaria. Physical chronic urticaria occurs due to the induction of external physical stimuli, such as scratches, sunlight, and pressure, whereas chronic spontaneous urticaria occurs without induction. 3 In some patients with chronic spontaneous urticaria, autoantibodies are found in their serum, so it is called autoimmune urticaria, while others with no autoantibodies found in their serum are called chronic idiopathic urticaria. 4 In most autoimmune urticaria patients, functional autoantibodies were found in the form of IgG antibodies against the α subunit of high-affinity IgE receptors (FcεRIα), while in others they were IgG antibodies against IgE. Cross-linking between IgG antibodies with FcεRIα or IgE will induce the release of vasoactive mediators through the activation and degranulation of basophils or mast cells. The release of vasoactive mediators by basophils or mast cells leads to increased