250 American Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS) ISSN (Print) 2313-4410, ISSN (Online) 2313-4402 © Global Society of Scientific Research and Researchers http://asrjetsjournal.org/ Relationship between Thyroid Profile with Reproductive Hormones and Semen Quality Khushbu Vaghela a* , Heena Oza b , Vinit Mishra c , Anil Gautam d , Yogendra Verma e , Sukhdev Mishra f , Sunil Kumar g a,d,e,f,g National Institute of Occupational Health, Ahmedabad, India b Department of Obstetrics and Gynecology, Civil Hospital, Ahmedabad, India c Institute of Kidney Diseases (IKD), Ahmedabad, India a Email: khushbu1702@gmail.com Abstract Semen quality is associated with various factors. The objective of the study was to investigate the impact of hypothyroidism and hyperthyroidism on human semen quality and reproductive hormones level if any. A total of 351 subjects were enrolled. They were subjected to assess the status of thyroid as well as reproductive hormones and semen quality. The subjects were grouped on the basis of thyroid hormone profile as, hypothyroid, hyperthyroid and normal thyroid hormone profile with respect to semen quality and reproductive hormones level. Semen volume, sperm count and viability was non-significant statistically in both hypothyroid and hyperthyroid subjects with respect to subjects with normal thyroid profile. Whereas, percent fast progressive Sperm was significantly lower in hypothyroid subjects, while non-motile sperm was significantly higher in hypothyroid subjects as compared to normal thyroid profile subjects. The data on reproductive hormones level indicated that FSH was higher and testosterone level was lower in both hypo and hyperthyroid subjects as compared to subjects with normal thyroid profile. Although the results were statistically non-significant. While LH level was also higher which was statistically significant in hypothyroid subjects with respect to subjects having normal thyroid profile. The data obtained suggest that impaired thyroid hormone has an impact on semen quality as well as reproductive hormone profile to some extent. Keywords: Semen quality; Testosterone; LH; Hyperthyroid; Hypothyroid. ------------------------------------------------------------------------ * Corresponding author.