Advances in Biological Research 7 (2): 50-58, 2013 ISSN 1992-0067 © IDOSI Publications, 2013 DOI: 10.5829/idosi.abr.2013.7.2.72134 Corresponding Author: Nishi Thakur, Department of Pharmaceutical Technology, Meerut institute of engineering and technology, MeerutNH-58, Baghpat Road, Near Baghpat Crossing, Pin code-250005, India. 50 Overview “A Novel Approach of Fast Dissolving Films and Their Patients” Nishi Thakur, Mayank Bansal, Neha Sharma, Ghanshyam Yadav and Pragati Khare Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut NH-58, Baghpat Road, Near Baghpat Crossing Pin code-250005, India Abstract: Recently, fast-dissolving drug delivery systems have started gaining fame and acceptance as new drug delivery systems, which aim to enhance safety and efficacy of a drug molecule by formulating it into a conventional oral dosage formfor administration and to achieve better patient compliance. Some companies introduced more robust forms of fast-dissolving drug delivery the film is placed on the top or the floor of the tongue. When put on the tongue, this film dissolves instantaneously, releasing the drug which dissolves in the saliva. Some drugs are absorbed from the mouth, pharynx and esophagus as the saliva passes down into the stomach. In such case is enhancing drug bioavailability, No risk of chocking, Provide good mouth feel. Fast dissolving drug delivery system to overcome this problemdifficulty in swallowing tablets/capsules etc. This review article overview the advancement in the oral dosage forms, application, formulation consideration, method of preparation, evaluation, marketed product and patented technologies of oral fast disintegrating films. Key words: Fast Dissolving Film Low Dose High Solubility High Permeability Patient Compliance INTRODUCTION FDF is prepared using hydrophilic polymer that Oral route is the most preferred route of delivering the drug to the systemic circulation via buccal administration for systemic effect. About 60% of all the mucosa [4]. formulations are solid dosage form. Tablet is the most The fast dissolving drug delivery system are preferred dosage form due to ease of transportation, specially designed for the drugs which have extensive manufacturing and more patient compliance [1]. first pass metabolism and have low dose, for the Generally geriatric, pediatric and bedridden patient enhancement of bioavailability [5]. experience difficulties in swallowing the conventional oral dosage form. To overcome this problem a novel Definition of FDF: Fast dissolving films are most advance formulation was developed i.e. oral fast dissolving films. form of solid dosage form due to its flexibility. It improve Fast dissolving films (FDF), a type of oral drug efficacy of Active pharmaceutical ingredient (API) delivery system for the oral delivery of the drug, was dissolving in the short duration oral cavity after the developed based on the technology of the transdermal contact with less amount of saliva as compared to patch. This delivery system consists of a thin film, which dissolving tablet. is simply placed on the patient’s tongue or mucosal tissue, instantly wet by saliva; the film rapidly dissolves. Then it rapidly disintegrates and dissolves to release the medication for oralmucosal absorption [2, 3]. This fast dissolving action is primarily due to the large surface area of the film, which wets quickly when exposed to themoistoral environment. Fig. 1: Fast dissolving oral film rapidly dissolves on the tongue or buccal cavity,