Research Article
Synthesis, Characterization, and Evaluation of
Antimicrobial and Antifertility Efficacy of Heterobimetallic
Complexes of Copper (II)
Ashu Chaudhary and Anshul Singh
Department of Chemistry, Kurukshetra University, Kurukshetra 136 119, India
Correspondence should be addressed to Ashu Chaudhary; ashuchaudhary21@gmail.com
Received 10 May 2017; Revised 6 July 2017; Accepted 30 July 2017; Published 2 October 2017
Academic Editor: Hakan Arslan
Copyright © 2017 Ashu Chaudhary and Anshul Singh. Tis is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
Heterobimetallic complexes of the copper with remarkable antimicrobial and antifertility action have been synthesized by the
conventional method by reacting CuCl
2
and o-phenylenediamine in the methanolic medium forming the mononuclear complex
of the type [Cu(C
6
H
8
N
2
)
2
]Cl
2
which was further treated with group 4 or 14 organometallic dichlorides (Ph
2
M
Cl
2
, Me
2
M
Cl
2
, and
Cp
2
M
Cl
2
) [M
= Sn, Si, and M
= Ti, Zr] leading to formation of heterobimetallic complexes. All the synthesized complexes were
characterized in the light of various physicochemical techniques like elemental analyses, conductivity measurements, molecular
weight determination, electronic and infrared spectra, electronic spin resonance, X-ray, and mass spectral studies. Te in vitro
antibacterial activity of synthesized complexes against Escherichia coli and Staphylococcus aureus was tested to evaluate their
inhibiting activities. Te antifungal activities of mono- and heterobimetallic complexes were studied by screening the compounds
against Fusarium oxysporum and Alternaria alternata. Tese complexes were then investigated to reveal their efect on the
reproductive organs of male rats. Te treatment has shown substantial decline in the sperm motility and density signifying the
imperious antifertility activity.
1. Introduction
Over the past few decades, studies on heterobimetallic
complexes have aroused as a conspicuous feld in the quest
for new chemistry because of their plausible applications in
fundamental, applied sciences, and coordination chemistry
benefcial in industrial and synthetic processes such as cataly-
sis, photochemistry, and biological systems. Heterobimetallic
complexes have gained augmented research interest in recent
years owing to the presence of two diferent metals which
contributes to captivating structures and results in imperative
applications.
In recent years, bimetallic complexes encompassing two
diferent metal centers have acknowledged escalated consid-
eration owing to the assumption that their reactivity should
vary signifcantly from that of monometallic complexes or
homobimetallic complexes [1]. Te physical properties of
these complexes are greatly afected by the presence of two
metals in the same molecule along with an appreciable change
in their reactivity. Tis is moreover due to the substantial
modifcation in the individual properties of the metals or
in the development of unique characteristics, which do not
occur in monometallic compounds [2]. Varying applications
of heterobimetallic complexes have been thoroughly explored
which are found to be arising from the bifunctionality of the
difering metal atoms [3].
Heterobimetallic complexes with transition metal ions
have been subject of interest and entangled in biological
processes of life [4]. Among the essential heavy metal ions
in the human body, Cu
2+
is third in abundance afer Fe
3+
and
Zn
2+
, and it plays very important role in several biological
processes. Furthermore, many bimetallic complexes embroil-
ing transition metals have been found to have potentials as
antibacterial, anticancer, and antidiabetic agents [5].
Te treatment of infectious diseases still remains an
important and exigent problem because of an amalgamation
Hindawi
Journal of Chemistry
Volume 2017, Article ID 5936465, 9 pages
https://doi.org/10.1155/2017/5936465