r A a l þ a t n ý i r j m i r a O O h r c i r g a i n e a s l e R Ozum Tuncyurek 1 , Ozlem Gunay 2 , Fatma Taneli 3 , Semin Ayhan 4 , Nalan Nese 4 , Yuksel Pabuscu 5 1 Aydin Ataturk Goverment Hospital, Radiology Dep, Aydin, 2 Biolab Laboratory Groups, Biochemistry Dep, Izmir, 3 Celal Bayar University Faculty of Medicine, Biochemistry Dep, Manisa, 4 Celal Bayar University Faculty of Medicine, Pathology Dep, Manisa, 5 Celal Bayar University Faculty of Medicine, Radiology Dep, Manisa, Turkey Melatonin Böbrek Yetmezliğinden Korur mu? / Is Melatonin Protect from Renal Failure? Is Melatonin Protective in Contrast Material Related Renal Failure? Melatonin Kontrast Madde İle İlişkili Renal Yetmezlikten Korur mu? DOI: 10.4328/JCAM.1929 Received: 03.06.2013 Accepted: 27.06.2013 Printed: 01.03.2015 J Clin Anal Med 2015;6(2): 186-9 Corresponding Author: Özüm Tunçyürek, Aydin Atatürk Devlet Hastanesi, Radyoloji Ultrason Bölümü, 09010 Aydin, Türkiye. GSM: +905301437669 F.: +90 2562252505 E-Mail: ozum.tuncyurek@gmail.com Özet Amaç: Çalışmanın amacı, erkek sıçanlarda myoglobinüri ve radyokontrast maddeye bağlı oluşan böbrekyetmezliğinde melatoninin etkisini araştırmak- tır. Gereç ve Yöntem: Anestezi eşliğinde,tüm sıçanların her iki arka bacağına eşit miktarda %50’lik gliserol uygulanarak myoglobinürik böbrekyetmezliği geliştirildi. 3 saatsonra :Grup I (n:7): Iopromide (Ultravist-300®) 2 ml/kg (int- rakardiak); Grup II (n:7): Iopromide(Ultravist -300®)ve intraperitoneal olarak Melatonin (10 mg/kg) ; Grup III (n:7): 2 ml/kg fizyolojik salin (Kontrolgrubu). Kan örnekleri toplanarak üre, kreatinin ve cystatin c değerleri çalışıldı. Proto- kolü bilmeyen iki patolog tarafından böbrekler incelendi. Bulgular: Grup 2 ile 3 arasında kreatinin ve cystatin c değerleriiçinfarkyoktu (p=0.9; 0.2). Tartış- ma: Çalışmada, kontrasta bağımlı böbrekte oluşan oksidatif stresin melato- nin ile önlenebildiğini gösterdik. Ancak, insanlar damelatoninin koruyucu etki- lerinin ekklinik çalışmalarla değerlendirilmesine ihtiyaç vardır. Anahtar Kelimeler Akut Böbrek Yetmezliği; Kontrast Bağımlı Nefrotoksisite; Lopromide Melatonin Abstract Aim: The aim of the study was to investigate the efect of melatonin on the renal injury resulting from radiocontrast media and myoglobinuria in male Wistar albino rats. Material and Method: 50% glycerol at equal amounts was intramuscularly administered to both hind legs of all animals under ether anesthesia at the dose of 10 mg/kg. Three hours later, the groups were ad- ministered the following: Group I (number:7): Iopromide(Ultravist -300®) at the dose of 2 ml/kg (intracardiac); Group II (number:7): Iopromide(Ultravist -300®) and intraperitoneally administered Melatonin at the dose of 10 mg/ kg (Melatonin was dissolved in 7.5% absolute ethanol and further dilutions were made in saline.); and Group III (number:7): 2 ml/kg of sterile physiologic saline (Control group). The levels of Uurea, Ccreatinine and Ccystatin C were studied on the blood samples collected. The renal samples were evaluated by 2two distinct pathologists who did not know the protocol. Results: There was no diference in the values of Creatinine and cystatin c between Groups 2 and 3 (p=0.9; 0.2). Discussion: In conclusion, we evaluated the possible prevention of contrast-induced oxidative stress in the kidney with using melatonin. How- ever, additional clinical studies are needed to evaluate the role of preventive melatonin treatment in humans. Keywords Acute Renal Failure; Contrast Induced Nephrotoxicity; Lopromide Media Melatonin | Journal of Clinical and Analytical Medicine 186