Accepted Manuscript Title: Towards a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment Authors: L´ ıgia C. Gomes-da-Silva, Adriana O. Santos, Lu´ ıs M. Bimbo, Vera Moura, Jos´ e S. Ramalho, Maria C. Pedroso de Lima, S´ ergio Sim˜ o es, Jo˜ ao N. Moreira PII: S0378-5173(12)00502-9 DOI: doi:10.1016/j.ijpharm.2012.05.018 Reference: IJP 12602 To appear in: International Journal of Pharmaceutics Received date: 26-2-2012 Revised date: 6-5-2012 Accepted date: 11-5-2012 Please cite this article as: Gomes-da-Silva, L.C., Santos, A.O., Bimbo, L.M., Moura, V., Ramalho, J.S., Lima, M.C.P., Sim˜ o es, S., Moreira, J.N., Towards a siRNA- containing nanoparticle targeted to breast cancer cells and the tumor microenvironment, International Journal of Pharmaceutics (2010), doi:10.1016/j.ijpharm.2012.05.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.