Int. J. Pharm. Sci. Rev. Res., 68(2), May - June 2021; Article No. 27, Pages: 183-193 ISSN 0976 – 044X International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net ©Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 183 Suraj B. Pund 1 *, Vishwas C. Bhagat 2 , Madhuri T. Deshmukh 3 , Rajkumar V. Shete 4 1 Research Scholar Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, India. 2 Department of Pharmaceutical Chemistry Rajgad Dnyanpeeth’s College of Pharmacy, Bhor. Dist- Pune. India. 3 Department of Pharmaceutics Rajgad Dnyanpeeth’s College of Pharmacy, Bhor. Dist- Pune, India. 4 Department of Pharmacology, Principal of Rajgad Dnyanpeeth’s college of Pharmacy, Bhor. Dist- Pune, India. *Corresponding author’s E-mail: surajpund143@gmail.com Received: 14-03-2021; Revised: 22-05-2021; Accepted: 30-05-2021; Published on: 15-06-2021. ABSTRACT The objective of present study aims to formulate enclosed floating alginate beads of Prochlorperazine Maleate (PCZM) for the treatment of nausea and vomiting. The Prochlorperazine Maleate which is having lower bioavailability up to 12.5% and also, it’s a lower biological half-life so which required multiple dosing frequencies 3-4 times a day. Bioavailability refers that to extend and rate at which the active moiety enters into the systemic circulation to the site of action. Biological half-life is the time that a body requires to eliminate one-half the quantity of an administered substance. So, by using Floating Alginate Beads of Prochlorperazine maleate which is help to Produced sustained released action up to 12 hours. Hence, it helpful for improvement of bioavailability and biological half-life, and reduced frequency of dosing. The Prochlorperazine Maleate (PCZM) beads were formulated by the Ionotropic gelation method by sodium alginate solution containing Low methylated pectin in various ratios. The Preformulation study was performed like Physical characters, Drug Excipients compatibility study by Calibration curve, FTIR and DSC study. The floating alginate beads were evaluated by different parameters like Percentage yield, Drug Content (DC) & Entrapment Efficiency (EE), In-vitro Drug Release study, particle size analysis, Z-Potential, SEM, PXRD, Stability study. The result of the FT-IR and DSC study indicated the stability and compatibility of the drug & polymers. The standard calibration curve in 0.1 N HCl (pH 1.2) showed a regression of 0.999. The percentage yield was found to be 86.29% to 95.90%. The drug content was found to be 3.7- 4.7 mg. The percentage buoyancy was found to be 89.40% to 97.50%. The in-vitro drug release study of the formulated batch was ranged from 77.29% to 91.44% at the end of 12 h. The best formulation was selected as batch B-2 which gives the best result based on Percentage Yield, DC, EE, buoyancy study, and In-vitro Drug Released study. Particle size observed in Nano range that is 393.3 nm and, Z-potential found to be -2.84mV. By Scanning Electron Microscopy (SEM) the beads were shown to be Spherical and slightly rough surface because of drying. A powdered X-Ray Diffraction study showed that the drug is converted from crystalline to an amorphous form. The B 2 Optimized batch drug content was found to be 4.62 mg and it is having no change in its physical appearance. Hence it shows good stability up to 60th day. Keywords: Prochlorperazine maleate, Sodium alginate, Pectin, Floating drug delivery, Ionotropic gelation. QUICK RESPONSE CODE → DOI: 10.47583/ijpsrr.2021.v68i02.027 DOI link: http://dx.doi.org/10.47583/ijpsrr.2021.v68i02.027 INTRODUCTION he objective of the drug delivery system is to deliver a therapeutic amount of drugs to the right place in the body to quickly reach them and maintain the proper desired concentration of drugs. The oral route increases progressively when used for the delivery of therapeutic agents due to the low compensation of the therapy and the ease of administration leading to get more patients satisfaction. Near about 50% or more drugs are in the oral drug delivery system available in the market. 1-3 Conventional (commercial) oral dosage forms offer no control over drug delivery, leading to fluctuations in the plasma drug concentration levels. These have the difficulty of releasing all or nothing from the emptying process, although the multi-unit particle system passes through the GIT to evade the vagaries of gastric emptying and thus release the drug more consistently. Numerous approaches have been developed to increase the retention of an oral dosage form in the stomach. for example, floating systems, expansion-by-expansion systems, muco-adhesive systems, and high-density systems. 4-6 Floating multiparticulate gastroretentive drug delivery systems based on effervescent and non-effervescent approaches. Hollow microspheres are, empty spherical particles without the nucleus in a severe sense, this alginate are typically free-flowing powders consisting of synthetic proteins or polymers, which are ideally spherical beads of approximately 2.5 mm diameter. 5-6 Microparticles are different spherical microcapsules that function as the solid substrate on which the drug is layered or encapsulated in the bead's core. Beads can provide controlled release properties and the bioavailability of pearl formulated drugs can also be improved. Floating alginate beads achieves the goal of developing a gastro- retentive drug delivery system is to maintain the drug's release action, as well as to improve the therapeutic effect Development and Characterization of Enclosed Prochlorperazine Maleate Floating Alginate Beads T Research Article