A review on biological activities of Schiff base ligand and their metal complexes *P.M. Jadhav * Department of Chemistry, Assistant Professor, ShriMuktanand College, Gangapur(MS), India. Abstract : Schiff bases and their metal complexes are wide range of biological applications and are synthesized from the condensation reaction of amino compounds with carbonyl compounds. Schiff base and their metal complexes have a wide variety of applications in food and dye industry, agrochemical, polymer, catalysis, analytical chemistry, antifertility, anti- inflammatory activity, antiradical activity, and biological system as enzymatic agents. Several have reviewed them of their antimicrobial, antibacterial, antifungal, antitumor, and cytotoxic activities. This review summarized the most promising biological activities of Schiff bases and their metal complexes. Keywords : Schiff bases, metal complexes, biological activity. Introduction: Schiff base in a broad sense have the general formula R 1 R 2 C=NR 3 , where R is an organic side chain. In this definition, Schiff base is synonymous with azomethine. Thus, the general formula RCH=NR [1]. Schiff base can be synthesized from an aromatic amine and a carbonyl compound by nucleophilic addition forming a hemiaminal, followed by a dehydration to generate an imine. Imines that contain an aryl group bounded to the nitrogen or to the carbon atom are called Schiff base(Fig.1)[2].Schiff base are capable of forming coordination bond with many metal ions through both azomethine group and phenyl group.Schiff base are capable of forming coordination bond with many metal ions through both azomethine group and phenyl group(Fig.2). Many Schiff bases were prepared by condensation reaction of certain aromatic amines a with aromatic aldehydes derivatives. Many Schiff bases were prepared by condensation reaction of certain aromatic amines a with aromatic aldehydes derivatives. Ar-NH 2 + Ar-CHO Ar-N=CH-Ar P.M. Jadhav et al /International Journal of ChemTech Research, 2020,13(1): 217-221. DOI= http://dx.doi.org/10.20902/IJCTR.2019.130126 International Journal of ChemTech Research CODEN (USA): IJCRGG, ISSN: 0974-4290, ISSN(Online):2455-9555 Vol.13 No.01, pp 217-221, 2020