* Corresponding author: Linahtadiya Andiani, linahtadiyaa@gmail.com DOI: 10.3269/1970-5492.2017.12.38 All rights reserved. ISSN: 2279-7165 - Available on-line at www.embj.org EUROMEDITERRANEAN BIOMEDICAL JOURNAL 2017,12 (38) 178–183 (FORMERLY: CAPSULA EBURNEA) Original article A NOVEL METHOD FOR ANALYZING ELECTRIC FIELD DISTRIBUTION OF ELECTRO CAPACITIVE CANCER TREATMENT (ECCT) USING WIRE MESH ELECTRODES: A CASE STUDY OF BRAIN CANCER THERAPY. Linahtadiya Andiani 1 , Endarko 1 , Mahfudz Al Huda 2 , and Warsito Purwo Taruno 2 1. Physics Department, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo-Surabaya 60111, Indonesia 2.CTECH Labs Edwar Technology,Jl. Jalur Sutera Kav. Spektra 23 BC No. 10-12 Alam Sutera, Tangerang, Banten, Indonesia A R T I C L E I N F O Article history: Received 30 September 2017 Revised 20 November 2017 Accepted 27 November2017 Keywords: ECCT, electric field distribution, wire mesh A B S T R A C T Electric field distribution analysis generated by ECCT in a human head model with or without brain cancer using wire mesh electrode has been conductedsuccessfully. The analysis of electric field distribution was done using simulation in a human head model with ECCT Apparel Helmet system type A which is three dimensional model. The electric field distribution was measured with and without a wire mesh electrode which was either passive or active using COMSOL Multiphysics 5.2 software and was then processed using MATLAB R2010a. The aim of the research was to assess the performance of wire mesh electrode in detecting electric field distribution. ECCT which is utilized in brain cancer therapy with input 10 V is able to produce an electric field with an average of 178.8 V/m. The input voltage influences electric field distribution whereas the signal frequency does not affect the electric field distribution. Wire mesh electrode which is either active or passive can measure the electric field distribution generated by ECCT that neither the active nor the passive wire mesh electrode changed the pattern of the electric field distribution and the change in the measured electric field value is not significant. © EuroMediterranean Biomedical Journal 2017 1. Introduction Brain cancer is a malignant brain tumor that is referred to as the silent killer due to rare early signs in sufferers. Death rates caused by cancer are still relatively high according statistical data from The Surveillance, Epidemiology, and End Results (SEER) from which it can be seen that the percentage of brain cancer patients who survive for five years after being diagnosed is 33.8%. One of the causes of the high death rate is the fact that healing methods are not yet at their most effective[1]. At present, the most common methods used to cure brain cancer are surgery, chemotherapy, and radiotherapy. Their costs are a relatively high and moreover they have an adverse effect on the normal tissue. Because of this, those cancer healing methods have not been used to the fullest extent to cure cancer. Electro Capacitive Cancer Treatment (ECCT) developed by Dr. Taruno P. Warsito is currently being developed as a therapy to destroy cancer cells using an electric field[2]. ECCT represents an electrical capacitance cancer therapy method. The method is based on the research of Yoram Palti who concluded that the growth of cancer cells could be inhibited or even turned off by the alternating electric field. The electric field can penetrate the cell membrane and affect the cell that is splitting[3]. The ECCT system for brain cancer therapy consists of a power supply that has an input voltage of around 2.4 to 3 V, a cable connector, and an apparel helmet. Markus Hardiyanto reported that ECCT with electrode configuration as shown in Figure 1 has an optimal configuration for therapy. This type is capable of generating an electric field with a wider area that can be used for cancer positioned in the majority of brain tissue[4].