www.wjpps.com Vol 4, Issue 06, 2015. 24 Omran et al. World Journal of Pharmacy and Pharmaceutical Sciences SYNTHESIS, ANALGESIC AND ANTIEPLIEPTIC PROPERTIES OF SOME NOVEL N-SUBSTITUTED SUCCINIMIDE Omran N. R. Fhid *1 ., Talal H. Zeglam 1 , Shaban E. A. Saad 2 ., Mohammed. Sh. Shlaka 1 ., Mohammed.A. Dao 1 1 Department of Medicinal & Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli 218- 21, Libya. 2 Department of Pharmacology, Faculty of Pharmacy, University of Tripoli, Tripoli 218-21, Libya. ABSTRACT The present study was aimed to study the analgesic and antiepileptic potency of some New succinimide derivatives. Various aromatic amines clubbed succinimide derivative compounds 2-13 were synthesized by using succinic anhydride and various amines in reflux synthesizer. The structures of the synthesized derivatives were confirmed by means of physical and spectral analysis. All the synthesized compounds were evaluated in vivo for analgesic and antiepileptic activities by using standard experimental models. The results indicated that most of them were found to exhibit good activity. KEYWORDS Succinimide, Analgesic activity, anticonvulsant activity, reflux synthesizer. 1. INTRODUCTION Cyclic imides are important family of organic compounds which exhibit a great variety of biological activities such as antifungal, antibacterial, antispasmodic and analgesic properties. [1-3] Some cyclic imides are used as plant growth regulators while others used as insecticides and some have important applications in medical field. [4-6] Substituted succinimide are important compounds of many drugs and drug candidates. One of the most fundamental objectives of organic and medicinal chemistry is the design and synthesis of molecules having value as human therapeutic agents. Cyclic imides and their WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 5.210 Volume 4, Issue 06, 24-34. Research Article ISSN 2278 – 4357 Article Received on 20 March 2015, Revised on 11 April 2015, Accepted on 02 May 2015 *Correspondence for Author Dr. Omran N. R. Fhid Department of Medicinal & Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Tripoli 218- 21, Libya.