IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 17, Issue 10 Ver. 3 (October. 2018), PP 14-17 www.iosrjournals.org DOI: 10.9790/0853-1710031417 www.iosrjournals.org 14 | Page Efficacy of Tetracycline Fibre as Local Drug Delivery over scaling and root planing in Nonsurgical Management of Chronic Periodontitis Dr. Babita Sahu 1 , Dr. Bhupendra Gathe 2 , Dr Harsh Salankar 3 , Dr Prashant Sawarkar 4 , Dr. Srikanth Guduguntla 5 , Assistant Professor, Dept of Dentistry, SSIMS, Bhilai, Chhattisgarh. Associate Professor, Dept of Physiology, SSIMS, Bhilai, Chhattisgarh. Professor, Dept of Pharmacology, SSIMS, Bhilai, Chhattisgarh. Associate Professor, Dept of Surgery, Seth GSMC & KEMH, Mumbai, Maharashtra. Professor, Dept of Periodontics, MCDRC, Durg, Chhattisgarh. Corresponding Author: Dr. Bhupendra Gathe Abstract Background- Periodontal disease is primarily caused by specific group of microorganisms which colonizes tooth surfaces in the form of a biofilm called dental plaque. Periodontal diseases include conditions such as chronic periodontitis, aggressive periodontitis and necrotizing periodontitis. Aim- To evaluate the efficacy of tetracycline fibres with scaling and root planing in reducing the clinical signs of periodontitis Materials and Methods- Study consisted of 60 sites of periodontal pocket of age group 25 – 55 years with chronic periodontitis. The selected sites were randomly divided into 2 groups: Group I (SRP alone) and Group II (SRP + tetracycline fibres) Plaque index, Gingival index, Sulcular bleeding index, Probing depth (PD) and Relative Attachment Level (RAL). After recording the clinical parameters from each site at baseline, a thorough scaling and root planing was done, using hand instruments and ultrasonic scaler in all groups. The clinical parameters were assessed at baseline, after 1 month & 3 months after receiving the treatment. Result- The development of sustained release delivery devices as tetracycline fibre as an adjunct to SRP showed greater improvement in respect to decreased probing depth and gain in clinical attachment level followed by scaling and root planing alone. There was significant improvement with respect to reduced gingival bleeding, minimal plaque accumulation from baseline to 3 months. Thus, tetracycline fibres as an adjunct to SRP proved to be efficient, safe, and cost effective for maintenance of periodontal disease than SRP alone. Keywords- Tetracycline fibre, Chronic Periodontitis, Scaling, Root planing, Local Drug Delivery --------------------------------------------------------------------------------------------------------------------------------------- Date Of Submission: 28-09-2018 Date of acceptance: 13-10-2018 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Chronic periodontal disease describes a group of related inflammatory reactions resulting in destruction of the tissues that support tooth in its socket. It results usually from extension of the inflammatory process initiated in the gingiva to the supporting periodontal tissues. The clinical findings include increased probing depth (PD), bleeding on gentle probing (BOP), loss of clinical attachment level (CAL) and alteration in the physiologic contour of the gingiva. Unfortunately, periodontitis cannot be cured, but it can be arrested. Traditional therapies for periodontal disease have included mechanical debridement to disrupt the subgingival flora and provide clean, smooth and biologically compatible root surfaces [1]. Various agents have been used to prevent further progression of periodontal disease either as monotherapy or as an adjunct to scaling and root planing procedure. These include tetracycline, doxycycline, minocycline, chlorhexidine, metronidazole, enzymes and quaternary ammonium compounds, which have been administered topically in pure forms by their incorporation in chewing gums, dentifrices, acrylic strips, hollow fibres, films, ointments, gel etc. It is clear that for local antimicrobial therapy to be clinically effective, successful mechanisms to deliver sustained and adequate concentration of the active agent to the periodontal pocket are required [2]. In order make use of tetracycline as local antimicrobial therapy, this study planned to evaluate efficacy of the drug. AIM To evaluate the efficacy of tetracycline fibres with scaling and root planing in reducing the clinical signs of periodontitis.