Int.J.Curr.Microbiol.App.Sci (2020) 9(3): 2427-2431 2427 Original Research Article https://doi.org/10.20546/ijcmas.2020.903.277 Efficacy of Intrauterine Hydrogen Peroxide and Povidone Iodine Administration to Treat Endometritic Mares Jugraj Singh Mahal 1 , M. Honparkhe 2 *, Ajeet Kumar 3 and Prahlad Singh 4 1 Khalsa College of Veterinary and Animal Science, Amritsar, India 2 Department Veterinary Gynaecology and Obstetrics, Guru Angad Dev Veterinary and Animals Sciences University, Ludhiana, Punjab 141004, India *Corresponding author ABSTRACT Introduction The mares suffer from various reproductive problems such as repeat breeding, an estrous, endometritis, abortions, retention of placenta and dystocia etc. Amongst all these disorders, endometritis has been reported to be the third most common medical condition in mares (Card 2005, Rasmussen et al., 2015) and is an important cause of reduced fertility. The mares if affected with persistent uterine infection may undergo abortions at various stages of gestation (Laugier et al., 2011). Following uterine fluid accumulation, the uterine defence mechanisms is compromised due to reduced phagocytosis, mucociliary clearance and lymphatic drainage resulting in to chronic endometrial dysfunction (Leblanc International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 3 (2020) Journal homepage: http://www.ijcmas.com The aim was to assess the comparative efficacy of intrauterine administration of hydrogen peroxide and povidone iodine solutions for the treatment of endometritis in indigenous mares. Twenty five mares with the history of regular estrus in a breeding season and turbid vaginal mucous discharge during estrus were included in the study. Following confirmation of endometritis through trans-rectal ultrasonography and uterine cytobrush, the animals were divided in to three groups at random on the basis of three intrauterine treatments. Group I(n=15) received 0.5% povidone solution 2.5 ml in 500 ml normal saline intrauterine on day 0 (day of presentation) followed by 500 ml intrauterine normal saline and intramuscular 20 I.U. oxytocin 6-8 h later. Group II(n=15) administered with 60 ml hydrogen peroxide (3%) intrauterine on day 0 followed by 500 ml intrauterine normal saline and intramuscular 20 I.U. oxytocin6-8 h later. Group III(n=5) received 500 ml intrauterine normal saline on day 0 followed by 20 I.U. oxytocin intramuscularly. The natural mating was advised during subsequent estrus if the vaginal mucus discharge found apparently clear. Post-treatment cure rates based on clear vaginal mucus were60%,80% and 40% in Group I, II and III, respectively. The conception rates were higher (P< 0.05) in Group I and II versus Group III (55.5%, 66.6% vs 50%, respectively). The intrauterine hydrogen peroxide and povidone iodine treatment proved beneficial to treat endometritic mares. Keywords Endometritis, hydrogen peroxide, mare, povidone Accepted: 20 February 2020 Available Online: 10 March 2020 Article Info