Methods: The enrolment sample comprised 85 persons. Inclusion criteria were (i) residency in the Canton Bern, (ii) age between 16 and 35 years and (iii) telephone number available. To preserve a high representativeness of the sample, exclusion criteria were restricted to (i) life-time diagnosis of psychosis and (ii) insuffi- cient language skills in German, French or English. 60 persons (70.5%) participated in the telephone interview, two of them met exclusion criteria. The 22 psychopathological at-risk symptoms were assessed for their occurrence and severity within the three months prior to the telephone interview using the (i) Schizophrenia Prediction Instrument, Adult version (SPI-A) for the evaluation of the 14 basic symptoms included in COPER and COGDIS and (ii) the Structured Interview for Prodromal Syn- dromes (SIPS) for the evaluation of the 5 APS and 3 BLIPS of the UHR criteria. Results: Only one person fulfilled APS-criteria according to SIPS, none BLIPS-criteria. Furthermore eight persons reported APS relevant symptoms but did not meet the occurrence and severity criteria for APS, and nine persons reported symptoms captured by the SIPS-P dimensions but "below" APS-rating. Nobody fulfilled at- risk criteria according to the basic symptom concept, although eight persons reported basic symptoms according to COPER and/or COGDIS but at an insufficient frequency or as lacking change (i.e. as a traitsymptom). Four persons reported both APS relevant symptoms plus COPER/COGDIS basic symptoms. Thus, altogether twelve persons (14.1%) had sub-threshold at-risk criteria for psychoses, and only one additional person (1.2%) actually met at- risk criteria. Discussion: The results indicate that the 3-months prevalence of at- risk criteria is similar to the incidence of psychotic disorders. This yields the conclusion that at-risk criteria are not as common as PLEs reported in epidemiological studies, and thus might be able to delineate a clinically relevant psychopathological state. These results, however, have to be confirmed in a larger sample. doi:10.1016/j.schres.2010.02.790 Poster 30 INFLUENCE OF PATERNAL AGE IN SCHIZOPHRENIA Franck schurhoff 1,2,3 , Alexandre Hubert 1,2,3,4 , Andrei Szoke 1,2,3 , Alexandre Meary 1,2,3 , Marion Leboyer 1,2,3 1 AP-HP CHU Chenevier-Mondor & INSERM U955 Creteil, Ile de France, France; 2 INSERM U955 Creteil, Ile de France, France; 3 University Paris XII Creteil, Ile de France, France; 4 Fondation FondaMental Creteil, Ile de France, France Background: Schizophrenia is an aetiologically heterogeneous syndrome, with a strong genetic component. Despite a reduced fertility in this disorder, its prevalence is maintained and could be explained by de novo genetic mutations. Advanced paternal age (APA) is a major source of new mutations in human beings and could thus be associated with an increased risk of developing schizophrenia in offspring. New mutations related to APA have been implicated as a cause of sporadic cases in several autosomal dominant diseases and also in neurodevelopmental diseases, autism, intellectual disabilities, and social functioning. The aim of the present study was to summarize the results of studies investigating the role of APA, and to discuss some interpretations. Methods: All relevant studies were identified through the National Library of Medicine (PubMed® database). Key-words used for research were "age" and "schizophrenia" linked to "paternal or father". We have identified and analysed 7 cohort studies, 4 case- control studies, 2 meta-analyses, and 1 review concerning different father's mutations potentially transmitted, 2 studies comparing paternal age at conception between sporadic versus familial cases of schizophrenia. All studies selected have been published between 2000 and 2009. Results: After controlling for several confounding factors including maternal age, the relative risk of schizophrenia increased from 1.84 to 4.62 in offspring of fathers with an older age of fatherhood. Mother's age showed no significant effects after adjusting for paternal age. There was a significant association between paternal age and risk of developing schizophrenia, there was a weaker association with psychosis. Discussion: The results of these different studies are confirmed by two recent meta-analyses which found an increased risk of schizophrenia in offspring of father older than 35 years. Two main hypotheses could explain these results. The first one is based on the presence of new mutations in the spermatogonia, possibly because of accumulating replication errors in spermatogonial cell lines. The second hypothesis is based on the fact that father with schizo- phrenia spectrum personality disorder, known to be genetically related to schizophrenia, could have an advanced age at conception. However, regarding this hypothesis, advanced maternal age at conception should be a risk factor for schizophrenia, and this is not the case. Thus, the first hypothesis seems more plausible than the second one. However, APA has been identified as a risk factor for other psychiatric disorders such as autism, bipolar disorder, phobia, and its association with impaired neurocognitive outcomes during infancy and childhood in normal populations raises the question of the phenotype linked to APA. Conclusion: APA at conception appears to be a risk factor for schizophrenia. To date, there is no validated cut-off at which the risk is significantly increased in offspring. In the future, studies could benefit from analyzing the phenotype related to APA. doi:10.1016/j.schres.2010.02.791 Poster 31 THE INFLUENCE OF MATERNAL SENSITIVITY, PARENTAL RELATIONSHIP AND CHILDHOOD SEXUAL ABUSE ON ADULT DELUSIONAL-LIKE EXPERIENCES: A BIRTH COHORT STUDY James G. Scott 1,2 , John J. McGrath 2,3 , Jake M. Najman 2 1 Royal Children's Hospital Brisbane, Queensland, Australia; 2 The University of Queensland Brisbane, Queensland, Australia; 3 Queensland Centre for Mental Health Research, Brisbane, Queensland, Australia Background: There is a growing body of research suggesting that exposure to childhood sexual abuse (CSA) is associated with delusional-like experiences (DLE) in adulthood. There is less information on the influence of factors such as maternal sensitivity and parental relationship during childhood on DLE in adulthood. The aim of this study was to examine the association between these childhood exposures and DLE in a birth cohort. Methods: The study was based on a birth cohort of 3617 young adults born between 1981 and 1984. Childhood sexual abuse was retro- spectively reported and categorised into absent, non-penetrative or penetrative abuse. Adult DLE were measured using the Peters Delusional Inventory at the 21 year follow up. Scales were developed using items pertaining to maternal sensitivity towards the offspring during infancy and at 5 years, use of physical discipline by the mother at 5 years and quality of parental relationship at 5 and 14 years. The association between maternal sensitivity, physical discipline, quality of Abstracts 429