This study assessed the impact of oral health on the quality of life of patients who had been diagnosed with cancer. Study Design: A cross-sectional study of 60 patients age 13 years or older who had chemotherapy-induced oral mucositis were included. The Oral Health Impact Profile (OHIP-14) was used. OHIP-14 scores were obtained by assigning a weight to each question according to the Likert scale. Results: For each dimen- sion, the maximum values of the OHIP-14 were functional lim- itation (105), pain (225), psychological distress (155), physical disability (160), psychological inability (130), social disability (81), and disability (120). Conclusion: Based on the results of this study it can be concluded that oral mucositis is a side effect that causes decreased quality of life for affected patients. PE-478 - OVEREXPRESSION OF P63 PROTEIN PLAYS A ROLE IN AGGRESSIVENESS IN ISOLATED, SYN- DROMIC, AND RECURRENT KERATOCYST ODONTO- GENIC TUMORS. BÁRBARA VANESSA DE BRITO MONTEIRO, CASSIANO FRANCISCO WEEGE NONAKA, RENATO LUIZ MAIA NOGUEIRA, ROBERTA BARROSO CAVALCANTI, MÁRCIA CRISTINA DA COSTA MIGUEL, ÉRICKA JANINE DANTAS DA SILVEIRA. FEDERAL UNI- VERSITY OF RIO GRANDE DO NORTE. Keratocyst odontogenic tumor (KOT) has potentially aggressive clinical behavior, a tendency to recur, and is asso- ciated with nevoid basal cell carcinoma syndrome. P63 plays a critical role in neoplasm biology, being involved in several as- pects of tumorigenesis. Materials and Methods: Seventeen cases of isolated, 17 syndromic, and 8 recurrent KOTs were selected for immunohistochemical analysis of p63. The positivity index (PI) was established. The parametric one-way ANOVA test was used with 5% significance. Results: P63 was expressed in the nuclei of all cases. The majority of the sample exhibited expression in all epithelial layers (64.28%). There was no sta- tistical difference in the PI for the primary, isolated, and recurrent KOTs (p ¼ 0.152). Conclusion: The p63 expression observed suggests the existence of a suprabasal proliferative compartment in epithelium. Expression of p63 protein may not be related to the differences in biologic behavior in isolated, syndromic, and recurrent keratocyst odontogenic tumor. PE-479 - PARTICIPATION OF HMLH1, MDM2, AND P63 IN LOWER LIP CARCINOGENESIS. MARIA LUIZA DINIZ DE SOUSA LOPES, DENISE HÉLEN IMACULADA PEREIRA DE OLIVEIRA, DMITRY JOSÉ DE SANTANA SARMENTO, LÉLIA MARIA GUEDES QUEIROZ, MÁRCIA CRISTINA DA COSTA MIGUEL, ÉRICKA JANINE DANTAS DA SILVEIRA. UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE. This study evaluated the epithelial expression of hMLH1, MDM2, and p63 in lower lip actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Study Design: Forty cases of AC and 40 cases of SCC underwent immunoperoxidase method analysis. A thousand cells of each case were counted for immunohistochemical analysis. The data were analyzed quanti- tatively, and expression was compared by Mann-Whitney, Stu- dent t-test, or one-way ANOVA (p  0.05). Results: The hMLH1 expression was higher in cases of AC without dysplasia or with mild dysplasia (721.23  88.116), whereas fewer positive cells were observed in lower lip SSCs (255.03  199.47) when compared to the AC group (p < 0.001). Immunoexpression of MDM2 and p63 was higher in SCCs than in AC (p ¼ 0.019 and p ¼ 0.045, respectively). Conclusion: Our results suggest that alterations in the epithelial immunoexpression of hMLH1, MDM2, and p63 in potentially malignant and malignant lip dis- ease are related to the process of lower lip carcinogenesis. PE-480 - TOMOGRAPHIC EVALUATION OF POSI- TIONING OF NASAL SEPTUM IN PATIENTS UNDER- GOING SURGICALLY ASSISTED MAXILLARY EXPANSION: PILOT STUDY. RENNAN LUIZ OLIVEIRA DOS SANTOS, MARIA LUÍSA SOARES, PRISCILLA FLORES SILVA, ANTONIO FIGUEIREDO CAUBI, FÁBIO LUIZ NEVES GONÇALVES, CARLOS HENRIQUE LAGES ZOLIN, GABRIELA SOUTO MAIOR. FOPeUPE. Surgically assisted maxillary expansion (EMCA) is a pro- cedure to correct the transverse discrepancy between the dental arches caused by maxillary atresia. The nasal cavity has a close relationship with the maxilla, so it is believed that EMCA may cause some degree of deviation of the nasal septum when the expander is activated and during expansion progression. Eleven young adults underwent computed tomography preoperatively (T1) and 3 months (T2) after EMCA. Measurements were per- formed using specific software (ONIS Ò 3.2) to measure the deviation of the nasal septum at T1 and T2. Septal deviation was present in 63.6% (T1) and 81.8% (T2) of cases. Distances of the nasal septum to the walls of the nasal cavity showed an increase at T2 compared to T1, although the difference did not reach statistical significance (p < 0.625). PE-481 - TUMOR THICKNESS AND PT-STAGE PREDICT OCCULT LYMPH NODE METASTASIS IN EARLY ORAL CANCER. NATALIE KELNER, ANA LUCIA NORONHA FRANCISCO, CLOVIS ANTONIO LOPES PINTO, CLAUDIA MALHEIROS COUTINHO CAMILLO, JOSE GUILHERME VARTANIAN, LUIZ PAULO KOWALSKI. ACCAMARGO CANCER CENTER. The clinical course of early carcinoma of the tongue and floor of the mouth is unpredictable. Various histopathological parameters of the primary tumor have been suggested as prog- nostic factors for use in clinical decision-making. We reviewed clinicopathological data from 165 patients diagnosed with clinical stage I-II. The predictive value of pathological T-stage, histological grade, and thickness with respect to occult cervical metastases and survival was analyzed. The overall occult nodal metastatic rate was 22.4% (29/129). Tumor thickness of 3 mm or greater, pT-stage, and histological grade were associated with a high risk of occult cervical metastasis. Occult metastasis reduced disease-specific survival (91.3% vs 63%) (p ¼ 0.001) and overall survival after 5 years (78.3% vs 49.5%) (p ¼ 0.038). The present study indicates that thickness, histological grade, and pT-stage have a strong predictive value for occult cervical metastasis in stage I/II oral carcinoma. Thus elective neck treatment is indicated for pT2 tumors exceeding 3 mm in thickness. PE-482 - USEFULNESS OF ORAL CYTOPATHOLOGY IN THE DIAGNOSIS OF PEMPHIGUS VULGARIS. KARIN GONÇALVES SOARES CUNHA, BRUNA LAVINAS SAYED PICCIANI, ARLEY SILVA JÚNIOR, GERALDO OLIVEIRA SILVA JÚNIOR, MARÍLIA HEFFER CANTISANO, ALBANITA VIEIRA OLIVEIRA, ELIANE PEDRA DIAS. ORAL AND MAXILLOFACIAL PATHOLOGY OOOO e226 Abstracts February 2014