www.tjprc.org editor@tjprc.org SYNTHESIS OF QUINOLINE DERIVATIVES USING MICROWAVE IRRADIATION: THEIR ANTI-CANCER ACTIVITY G. PAVANA KUMARI 1 , NAVEEN MULAKAYALA 2 & VARIMADUGU ARUNA 3 1 Department of Chemistry, Sri Satya Institute of Higher learning, Anantapur-515001, India 2 SVAK Life Sciences, ALEAP Industrial Area, Hyderabad-5000090, India 3 Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad- 500075, India ABSTRACT Simple and catalyst free preparation of quinolin-6-ones were synthesized by the reaction of 4-chloro-4H-chromene-3- carbaldehyde and different amines using microwave irradiation. All the reactions were preceded smoothly by yielding good to better yields. The synthesized compounds were active against several cancer cells. KEYWORDS: Quinoline, Amines, Microwave, Anti-Cancer Activity Received: Sep 07, 2021; Accepted: Sep 27, 2021; Published: Dec 30, 2021; Paper Id.: IJBRDDEC20213 INTRODUCTION Coumarins are having diverse pharmacological activities in medicinal chemistry. Their core contains many active biological molecules used in the treatment of AIDS and cancer [13] Blend of chromene with a quinoline moiety showing great bioactivity against malignancy cell lines. By knowing the anticancer activity of coumarins and chromenes [4] , we want to synthesize quinolin-6-one derivatives by using microwave irradiation which are having anticancer properties. For the past few years, our team was working on the development of novel methods which are reusable and on the development of pharmaceutical products including impurities. [5-10] In this paper we describe the synthesis of quinolin-6-ones utilizing microwave light alongside their cancer activity corresponding to the synthesized molecules. RESULTS AND DISCUSSION Previously, quinolin-6-ones were prepared from 4-chloro-4H-chromene-3-carbaldehyde using AlCl3 as a catalyst, 11 Ultrasound 12 or via other methods. To overcome the disadvantages, we were keen on fostering another impetus free strategy for the amalgamation of quinolin-6-ones. For this, we developed an microwave assisted synthesis of quinolin-6-ones (3) by the reaction of 4-chloro-4H-1-benzopyran-3-carboxaldehyde (1) and different anilines (2). Primarily, we screened the reactions between aldehyde 1 with aniline (2a) using different solvents and found that DMF is the for this process. Original Article International Journal of Biological Research and Development (IJBRD) ISSN (P): 2250–0022; ISSN (E): Applied Vol. 11, Issue 2, Dec 2021, 19–24 © TJPRC Pvt. Ltd.