DOI: https://doi.org/10.24820/ark.5550190.p011.098 Page 1 © AUTHOR(S) The Free Internet Journal for Organic Chemistry Paper Archive for Organic Chemistry Arkivoc 2019, part ii, 0-0 to be inserted by editorial office Synthesis and biological evaluation of new indole and pyrrole carboxamides based on amino acids Martina Palomba, Sara Pompei, Luca Roscini, and Luana Bagnoli* Department of Pharmaceutical Sciences University of Perugia, Via del Liceo 1, 06123 Perugia, Italy Email: luana.bagnoli@unipg.it Dedicated to Professor Lorenzo Testaferri in the occasion of his 75 th birthday Received 10-28-2019 Accepted 12-19-2019 Published on line 01-05-2020 Abstract A new series of indole carboxamides have been synthesized through coupling reactions. Several substitutions on the aromatic ring and on the amino acids are well tolerated, and the corresponding indole carboxamides have been obtained with good yields. The same procedure can be also extended to the pyrrole nucleus. Four of these compounds have been screened for their antimicrobial activity against ten different yeast strains and two of them showed an antifungal activity. Further explorations are required to clarify a potential applicability in biological fields. Keywords: Amino acid, carboxamide, indole, pyrrole, amide bond.