2017 Vol. 2 No. 2: 10 iMedPub Journals www.imedpub.com Research Article 1 © Under License of Creative Commons Attribution 3.0 License | Find this article in: http://biomedicine.imedpub.com/ Insights in Biomedicine ISSN 2572-5610 DOI: 10.21767/2572-5610.100026 Yakubu OE, Olawale O, Arowora KA and Imo C Department of Biochemistry, Faculty of Pure and Applied Sciences, Federal University of Wukari, Nigeria Corresponding author: Dr. Ojochenemi E. Yakubu  oj4real_2007@yahoo.co.uk Department of Biochemistry, Faculty of Pure and Applied Sciences, Federal University of Wukari, Nigeria. Tel: 2348069078726 Citaton: Yakubu OE, Olawale O, Arowora KA, et al. Biochemical Changes in Haematological and Liver Functon Parameters in Intoxicated Male Albino Rats Treated with Hymenocardia acida Leaves Ethanolic Extract. Insights Biomed. 2017, 2:2. Introducton The use of herbal medicines in human and animal health care systems is well documented in ancient literature. In many parts of the World, ethno-therapies are no longer seen as myth, superstton, witchcraf or ungodly practces and indeed is gaining popularity with the belief that “natural is beter”. It is believed that nearly 80% of world populaton relies primarily on herbal remedies for the treatment of human and animal diseases. It is in this light that World Health Organizaton encourages the use of herbal preparatons for the treatment of some local health problems partcularly in developing countries where they are readily available, easily afordable and already integrated into the people’s cultures. Several medicinal plants have been proved benefcial through extensive laboratory tests [1]. In many African countries, herbal remedies play important role in the health of millions of people, partcularly the poor living in rural and peri-urban areas where medicinal plants are mostly available and afordable [2]. Generally, people begin treatng themselves using medicinal plants before going to an herbalist or modern doctor. It is a common practce in Nigeria that herbal products are administered over prolonged period and by persons that have litle or no knowledge of science [3,4]. Hymenocardia acida (Tul.) is a small brown tree or shrub with palatable foliage, widely distributed within the savanna region of Nigeria. Several researchers have reported the antmicrobial actvites [5], ant-ulcer [6], ant-diarrhoeal [7], ant-HIV and ant- infammatory [8] actvites of H. acida. Despite the acclaimed popular and numerous therapeutc benefts of H. acida, litle is known about its efects on Aluminium chloride- Abstract In the current study, the biochemical changes in haematological and liver functon parameters in Intoxicated Male Albino Rats treated with Hymenocardia acida leaves ethanolic extract on AlCl 3 -toxicity was investgated. Twenty albino rats assigned to four groups of fve each were used. Exactly 100 mg/kg bw of the plant extract was administered to groups 3 and 4 for the experimental period of seven days. At the end of the experimental period, animals were sacrifced and blood collected by cardiac puncture. Biochemical, haematological parameters and Thiobarbituric acid reactve substances (TBARS) were determined. The levels of all serum biochemical parameters measured (alanine transaminase (ALT), apartatate transaminase (AST), alkaline phosphatase (ALP), Glucose, Potassium and total Biliribin) in the aluminium chloride (AlCl 3 )-induced (negatve control) increased signifcantly (p<0.05) when compared with the normal control, while the ethanolic leaves extract non-signifcantly (p>0.05) decreased some of these parameters. Furthermore, the leaves extract showed a slight moderaton efect on selected haematological parameters. However, comparatve efect of the leaves extract on the normal control and on the negatve control show that the leave could possibly be toxic. This result show that the ethanolic extract of Hymenocardia acida leaves may possess mild amelioratve efect against aluminium chloride-induced toxicity and may also be toxic in male albino rats. Keywords: Hymenocardia acida; Kidney; Lipid peroxidaton; Liver; Toxicity Biochemical Changes in Haematological and Liver Functon Parameters in Intoxicated Male Albino Rats Treated with Hymenocardia acida Leaves Ethanolic Extract Received: March 25, 2017; Accepted: May 24, 2017; Published: May 29, 2017