Int.J.Curr.Microbiol.App.Sci (2017) 6(7): 4609-4614 4609 Original Research Article https://doi.org/10.20546/ijcmas.2017.607.483 Prophylactic Efficacy of Self-Formulated Anti-Oxidant Mineral Formulation for Mastitis Management in Dairy Cattle A. Muhee 1* , H. U. Malik 1 , I. Asharaf 1 , O. S. Shah 1 , A. Jan 1 , Muheet 1 , W. Rather 1 and Showkeen Muzamil 2 1 Department of Veterinary Medicine ethics and Jurisprudence, F.V.Sc & A.H, SKUAST-K, Srinagar- 192301, Jammu and Kashmir, India 2 Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K-190006, India *Corresponding author ABSTRACT Introduction Mastitis is characterized by a range of physical and chemical changes of the milk and pathological changes in the udder tissues (Radostits et al., 2007). It is still recognized as number one problem in dairy animals which results in great economic losses to the farmers due to reduced productivity and cost of treatment (DeGrave and Fetrow, 1993). So far, conventional antibiotic therapy is the only proven method for the prevention and control of mastitis, however, standard antibiotic treatment has not reduced the incidence of mastitis and antibiotics do not directly protect the gland from being damaged. In fact, several problems arise from the use of antibiotics for example, developing resistance to antibiotic, questionable drug efficacy and presence of antibiotic residues in the milk. Additionally, mastitis causes a rise in antimicrobial usage (Grave et al., 1999). During mastitis there is a large increase in the The study was undertaken on clinical cases of bovine mastitis presented to Teaching Veterinary Clinical Complex (TVCC), F.V.Sc & A.H, SKUAST-K and adjoining areas during the course of study August 2014-May 2016. For prophylactic trials, Twenty recently parturated lactating animals maintained at Mountain Livestock Research Institute (MLRI), SKUAST-K, Manasbal under similar managemental conditions but having susceptibility to occurrence of mastitis (as evidenced by precedence to occurrence of mastitis in previous lactations) were studied. Animals were divided into two groups, Group I comprising of ten animals received self-formulated anti-oxidant trace mineral mixture for a period of thirty days while as the other group (Group II) did not receive any anti- oxidants. The feeding of anti-oxidant trace mineral formulation improves the udder health status indicating increased capability of udder to defend against the attack of pathogenic microorganisms responsible for causing mastitis and hence decreased susceptibility to the occurrence of mastitis. Anti-oxidant trace mineral supplementation like Cu, Zn, Mn and Se may play a significant role in prophylaxis of mastitis in lactating animals. Keywords Mastitis, mineral mixture, supplementation, Scc Accepted: 20 June 2017 Available Online: 10 July 2017 Article Info International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 7 (2017) pp. 4609-4614 Journal homepage: http://www.ijcmas.com