173 JKMU Journal of Kerman University of Medical Sciences, 2021; 28 (2): 173-178 The Association of Psoriatic Arthritis with Carotid Intima-Media Thickness Hamidreza Talari, M.D. 1 , Mojtaba Sehat, Ph.D. 2 , Mohammad Shayestehpour, Ph.D. 3 , Khatereh Minaee, M.D. 4 , Batool Zamani, M.D. 5 1- Associate Professor, Department of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran 2- Associate Professor, Department of Community Medicine, Kashan University of Medical Sciences, Kashan, Iran 3- Assistant Professor, Autoimmune Diseases Research Center & Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran 4- Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran 5- Associate Professor, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran (Corresponding author: Email: batol_zamani2007@yahoo.com) Received: 6 September, 2020 Accepted: 9 January, 2020 ARTICLE INFO Article type: Original Article Keywords: Arthritis Psoriatic Carotid Intima-Media Thickness Abstract Background: Previous studies have showed that psoriatic arthritis increases the risk of cardiovascular disease and atherosclerosis. On the other hand, an increased carotid intima- media thickness can be associated with atherosclerosis. The present study aimed to evaluate the association between psoriatic arthritis and carotid intima-media thickness. Methods: In this case-control study performed during 2018, 22 patients with psoriatic arthritis and 22 healthy controls matched for age and sex were participated. In all subjects, the carotid intima-media thickness was measured by ultrasonography. Systemic inflammatory markers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were assessed in psoriatic arthritis patients. Results: The mean carotid intima- media thickness was 56±0.10 mm in the psoriatic arthritis patients and 54±0.07 mm in the control group with no significant difference (p=0.358). According to the regression analysis, carotid intima-media thickness had no positive correlation with age, sex and body mass index. The carotid intima-media thickness increased in psoriatic arthritis patients with increasing the duration of arthritis, disease activity (DAS- 28), CRP, and ESR, but the correlations were not statistically significant. Conclusion: The study findings do not support the previous reports that claimed a potential correlation between mean carotid intima-media thickness and psoriatic arthritis. Copyright: 2021 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Citation: Talari H.R, Sehat M, Shayestehpour M, Minaee Kh, Zamani B. The Association of Psoriatic Arthritis with Carotid Intima-Media Thickness. Journal of Kerman University of Medical Sciences, 2021; 28 (2):173-178. Introduction Psoriatic arthritis (PsA) is a rheumatoid-like arthritic disease characterized by inflammation, pain, and swelling in the joints of patients with psoriasis (1). This disorder occurs in up to 42 % of patients suffering from psoriasis and affects approximately 0.1–1.0 % of the general population (2). Previous studies have showed that psoriasis increases the risk of cardiovascular disease and atherosclerosis (3, 4).