Vrunal et al. / SGVU Journal of Pharmaceutical Research & Education, 2019, 4(1), 359-365 359 Review Article SGVU Journal of Pharmaceutical Research & Education Journal homepage: http://www.gyanvihar.org/researchjournals/ MICROSPONGE DRUG DELIVERY: A REVIEW Prajakta K.Khule 1* , Manoj M. Nitalikar 3 , Vrunal V. More 3 , Ritu M Gilhotra2 1.* SVERI’s College of Pharmacy, Pandharpur. 2. Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, Jaipur. 3. Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Sangli. Corresponding Author: Prajakta K.Khule. Mob.No-+91-9665196666. pkkhule@cop.sveri.ac.in, khulepk@gmail.com, ABSTRACT Microsponges is a novel approach which offers numours advantages for drug delivery. Microsponges drug delivery system is employed for the improvement of performance of orally, parenteral and topical administered drugs in verious diseses. Microsponges also offers release of drug at specific site in can circulate into the whole body and release the drug at a specific site in a controlled manner. Microsponges consists of macroporous beads, typically 10-25 micron in diameter, loaded with active agent. Microsponge drug delivery can provide increased efficacy for topically active drugs with enhanced safety, improved product stability and improved aesthetic properties in an efficient and novel manner. Microsponges mostly used for topical use and have recently been used for oral administration. So microsponge drug delivery system has got a lot of prospective and is a very emerging field which is needed to be explored in the future with most research study. Key words: Pharmacosomes, Amphiphilic Compounds, Carrier Mediated Drug Delivery, glycerylmonooleate, lipid crystal. INTRODUCTION The Won developed microsponge technology in 1987 & filled original patent for the same and it is assigned to polymer system. Their company developed with variations various products for pharmaceutical and cosmetic use. Microsponges consist of polymeric drug delivery system porous microspheres. They are sponge like structure consisting of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface and spherical in shape. Microsponges are highly stable with less side effects and having ability of modifying drug release. The microsponges are spherical in nature and having particle size ranging from 5-150 µm. 1 Microsponges are the cross-linked, porous, polymeric microspheres which acquire the