_____________________________________________________________________________________________________ *Corresponding author: E-mail: si.ogenyi@unizik.edu.ng; European Journal of Medicinal Plants 9(3): 1-8, 2015, Article no.EJMP.17883 ISSN: 2231-0894 SCIENCEDOMAIN international www.sciencedomain.org Effect of Ethanolic Crude Extracts of Nauclea latifolia Smith (Rubiaceae) Leaves, Fruits, Stem and Root Barks on the Liver of Chinchilla Rabbit S. I. Ogenyi 1* , A. A. Ngokere 1 , A. O. Onyemelukwe 1 , T. P. P. Choji 2 , A. O. Oluboyo 1 , R. C. Chukwuanukwu 1 , E. N. Ekekwe 1 and P. O. Manafa 1 1 Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria. 2 Department of Histopathology, National Veterinary Research Institute, Vom, Nigeria. Authors’ contributions This work was carried out in collaboration between all authors. Authors SIO, AAN and AOO designed the study, wrote the first protocol and wrote the first draft of the manuscript. Authors AOO, RCC and TPPC managed the analysis of the study. Authors ENE and POM did the literature searches. All authors read and approve the final manuscript. Article Information DOI: 10.9734/EJMP/2015/17883 Editor(s): (1) Marcello Iriti, Professor of Plant Biology and Pathology, Department of Agricultural and Environmental Sciences, Milan State University, Italy. Reviewers: (1) Ogunwande Isiaka Ajani, Department of Chemistry, Lagos State University, Nigeria. (2) Atef Mahmoud Mahmoud Attia, Biochemistry Department, National Research Centre, Egypt. Complete Peer review History: http://sciencedomain.org/review-history/9759 Received 29 th March 2015 Accepted 18 th May 2015 Published 15 th June 2015 ABSTRACT Aims: To determine the histopathological and biochemical effects of ethanolic crude extracts of Nauclea latifolia leaves, fruits, stem and root barks on the liver of Chinchilla rabbit. Study Design: This is an experimental study. Place and Duration of Study: The study, which lasted for 10 weeks, was carried out at the Animal House of the College of Health Sciences, Nnamdi Azikiwe University, Nnewi campus. Methodology: Twenty four (24) Chinchilla rabbits of both sexes were grouped into 4 (A-D). Group A-C received, orally, 100 mg/kg, 150 mg/kg and 250 mg/kg body weight of the extract respectively per day. Group D (control group) received equal volume of normal saline, in addition to normal diet and water. Blood and tissue specimens were collected under chloroform euthanasia after 60 days. Original Research Article