_____________________________________________________________________________________________________ *Corresponding author: E-mail: Reemaawad.17@gmail.com; Journal of Pharmaceutical Research International 33(48A): 245-254, 2021; Article no.JPRI.75101 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) The Prevalence of using Prescribed & Unprescribed “Roaccutane (Isotretinoin)” among Females Riyadh, Saudi Arabia: A Cross Sectional Study Mahmoud A Mahmoud 1 , Reem A. Almohaini 1 , Raghad A. Assiri 1 , Reema A. Alkhatabi 1* , Reema S. Alobaishi 1 and Rola F. Alharbi 1 1 College of Medicine, Imam Mohammad ibn Saud Islamic University, Riyadh, Saudi Arabia. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i48A33246 Editor(s): (1) Prabakaran Nagarajan, The Ohio State University, USA. (2) Ana Cláudia Coelho, University of Trás-os-Montes and Alto Douro, Portugal. Reviewers: (1) Dwi Aris Agung Nugrahaningsih, Universitas Gadjah Mada, Indonesia. (2) Arun K. Soni, SSR College of Pharmacy, Savitribai Phule Pune University, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/75101 Received 24 August 2021 Accepted 29 October 2021 Published 06 November 2021 ABSTRACT Aims: To determine the prevalence of using prescribed and unprescribed Isotretinoin and to assess knowledge of its adverse effects among females in Riyadh, SA. Study design: cross-sectional study. Place and Duration of Study: online questionnaire collected throughout two months by distributing the questionnaire via. social media platforms. Methodology: We included 385 female patients (age range 15-45 years) use Roaccutane (Isotretinoin) with or without prescribed. Statistical analysis was performed using Rv 3.6.3. Counts and percentages was used to summarize the distribution of categorical variables and data. Chi- square test was used to estimate the association between categorical variables. Hypothesis testing was performed at a 5% level of significance. Results: 568 respondents completed the questionnaire. Of these, 440 were from Riyadh. The majority of respondents were aged 15 – 20 (46.4%) and 21 – 25 (35.2%). Knowledge regarding some side effects of Roaccutane was significantly higher in respondents who reported using Roaccutane than those who did not. Knowledge of dry and cracked lips as a side effect was Original Research Article