Applied Medical Informatics Original Research Vol. 30, No. 2 /2012, pp: 47-56 Copyright ©2012 by the authors; Licensee SRIMA, Cluj-Napoca, Romania. 47 Accuracy of Neutrophil Gelatinase-Associated Lipocalin in Detecting Acute Kidney Injury after Urogenital Robotic Assisted Laparoscopic Surgery under General Anesthesia Orsolya MIHÁLY 1,* , Sorana D. BOLBOACĂ 2 , Rodica RĂHĂIAN 3 , Constantin BODOLEA 4 , Cipriana CHIRA 4 , Tudor CRISTEA 4 , Ana OBLEZNIUC 4 , Zoltán A. MIHÁLY 5 , Ioan COMAN 5 1 County Urgency Clinical Hospital Cluj, ICU and Anesthesiology II Department. Cluj Napoca 1-3 Clinicilor, 400006 Cluj Napoca, Cluj, Romania. 2 “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Department of Medical Informatics and Biostatistics, 6 Louis Pasteur, 400349 Cluj-Napoca, Cluj, Romania. 3 County Urgency Clinical Hospital Cluj, Immunology Department. Cluj Napoca 1-3 Clinicilor, 400006 Cluj Napoca, Cluj, Romania. 4 City Clinical Hospital Cluj, ICU and Anesthesiology Department, 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania. 5 City Clinical Hospital Cluj, Urology Department. 11 Tabacarilor, 400139 Cluj Napoca, Cluj, Romania. E-mail(s): Mihaly.Maria@umfcluj.ro; sbolboaca@umfcluj.ro; rodirahaian@yahoo.com; bodolea@yahoo.com; ciprianachira@yahoo.com; oblezniuc_ana@yahoo.com; mzattika@yahoo.com; jcoman@yahoo.com * Author to whom correspondence should be addressed; Tel.: 0040-745398005 Received: 10 April 2012 / Accepted: 30 May 2012 / Published online: 13 June 2012 Abstract The aim of this study was to demonstrate the accuracy of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in detecting Acute Kidney Injury (AKI) after urogenital robotic surgery in general anesthesia. Methods: A prospective longitudinal observational study, which included patients scheduled for elective robotic surgery under general anesthesia. The serum and urine NGAL at induction, 6 hours and 12 hours were determined. Serum creatinine was measured preoperatively and daily 4 days postoperatively. AKI was defined as the absolute growth of serum creatinine by 0.3 mg/dl over baseline within 48 hours postoperatively. Results: 24 patients were enrolled in the study. AKI occurred in 38% of patients. Serum NGAL increased significantly at 6 hours and 12h, compared to baseline, with a higher increase in the group of patents without AKI. There were no significant results for urine NGAL. A link was observed between the values of serum NGAL, with associated significance p<0.0001. The correlations between urine NGAL were not significant. The predictive value of NGAL, analyzed by cross-tabulation, OR was 3 for baseline value and 5.33 for the values measured at 6 hours and 12 hours, but with no statistical significance. Conclusions: The modifications of the NGAL levels, measured at 6 hours and 12 hours from the induction of anesthesia, were significant with more importance at 6 hours and in patients without AKI. Serum NGAL had no predictive value for AKI, but the risk to develop AKI was 3 times higher for baseline determination and 5 times at 6 and 12 hours. Keywords: Acute kidney injury; Biomarker; Neutrophil gelatinase associated lipocalin; General anesthesia; Robotics.