  H B @ . 1  D  P  ,B    H ,75F  ,B ,MA02120, A   +B M N  2016         1   1   1   1     D   (DOAC )   P   D   IN A ,  ( E),         -      1 . E    500,000      .A - ,        -          24 .A           E. O   K  ( KA),  ,            E  .    ,     ,       ,  -  ,   ,  -      57 . ,    (DOAC ), - , ,   ,       E.D    -       . - , ,       .DOAC      KA,     ,    , - able pharmacokinetic profles, decreased coagulation moni- ,    8 10 . M       DOAC            E         11 15 .A   ,     A    ED -    DOAC         ( E) has been confned to parenteral agents and oral vitamin K   ; ,         (DOAC ),     .                E    . A            E  - . O   105     , 45 (43%)     60 (57%)    DOAC.      most common DOACs initiated. There were signifcantly         CC  <60 /        DOAC (77.8% . 15%; P < 0.05). There were signifcantly less                 -       DOAC (15.6% . 55%; P <0.05). P     DOAC            (  2.5 I 0 4  . 6  I 5 7 ,  <0.05).P    DOAC             (  3 I 24 . 8  I 6 10 ,  <0.05).     DOAC           new onset VTE. Renal and liver function may infuence   .  DOAC        . 1 3 J Thromb Thrombolysis (2017) 43:74–78 DOI 10.1007/s11239-016-1417-5 Published online: 3 September 2016