_____________________________________________________________________________________________________ *Corresponding author: E-mail: emmanuelobeagu@yahoo.com; Journal of Pharmaceutical Research International 33(42A): 53-65, 2021; Article no.JPRI.72825 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Evaluation of Levels of Some Inflammatory Cytokines in Preeclamptic Women in Owerri Obioma Raluchukwu Emeka-Obi 1 , Nancy C. Ibeh 1 , Emmanuel Ifeanyi Obeagu 2* and Hope M. Okorie 2 1 Department of Medical Laboratory Science, Faculty of Health Science and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria. 2 Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i42A32384 Editor(s): (1). Dr. Rafik Karaman, Al-Quds University, Palestine. Reviewers: (1) Musa Ibrahim Kurawa, Bayero University, Nigeria. (2) Kaustav Chakraborty, S.B.S. Government College, University of Gour Banga, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/72825 Received 15 June 2021 Accepted 19 August 2021 Published 25 August 2021 ABSTRACT Preeclampsia is a serious and life-threatening pregnancy complication. In this study, the levels of inflammatory cytokines were measured in preeclamptic women in Owerri, Imo State. A total of 120 pregnant women aged 18-45 years at 20-40 weeks of pregnancy were recruited; 60 were preeclamptic women (test group) while 60 were normotensive pregnant women (control group). Preeclampsia was determined by the presence of ≥2+ protein in the urine using combi 2 dipstick for urinalysis and sphygmomanometer blood pressure reading of ≥ 140/90 mmHg. From the demographic data obtained in the studied subject through questionnaire, it showed that nulliparity and family history of high blood pressure were the most dominant risk factor of preeclampsia. The mean of the pro-inflammatory cytokines (IL-6 and TNF-α) in the test group were 4.33±1.42 pg/ml and 8.23±2.73 pg/ml while that of the control group were 3.38±1.22 pg/ml and 6.89±1.88 pg/ml. There was a significant increase in the pro-inflammatory cytokines of the preeclamptic women when compared to the control group. The mean of the anti-inflammatory cytokines (IL-10 & IL-4) of the group were 78.88±14.28 pg/ml and 27.92±7.22pg/ml while the control group was 91.39± 18.46 Original Research Article