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Electronic Journal of General Medicine 2020, 17(6), em234 e-ISSN: 2516-3507 https://www.ejgm.co.uk/ Original Article OPEN ACCESS Application of New TOPSIS Approach to Identify the Most Significant Risk Factor and Continuous Monitoring of Death of COVID-19 Priyanka Majumder 1 *, Piyali Biswas 2 , Srestha Majumder 3 1 Department of Basic Science and Humanities, Techno College of Engineering Agartala, Maheshkhola-799004, Tripura, INDIA 2 Department of Physics, National Institute of Technology Agartala, Jirania-799046, Tripura, INDIA 3 Department of Computer Science Engineering, Techno College of Engineering Agartala, Maheshkhola-799004, Tripura, INDIA *Corresponding Author: majumderpriyanka94@yahoo.com Citation: Majumder P, Biswas P, Majumder S. Application of New TOPSIS Approach to Identify the Most Significant Risk Factor and Continuous Monitoring of Death of COVID-19. Electron J Gen Med. 2020;17(6):em234. https://doi.org/10.29333/ejgm/7904 ARTICLE INFO ABSTRACT Received: 5 Apr. 2020 Accepted: 6 Apr. 2020 A pandemic is a disease that spreads across a large area like multiple continents or worldwide. More than 211 nations are already affected by Covid-19. The World Health Organization (WHO) on 11 March 2020 declared Covid- 19 a pandemic. There are more than 1,282,931 cases of the coronavirus illness over 211 countries and territories around the world. Currently coronavirus has no proper treatment in Medical Science, increasing the number of affected people day by day with the number of cases worldwide of novel coronavirus surpassing 1,282,931, with some 72,616 deaths approximately. That is why the main objective of the present investigation is to identify the significant risk factor. Also, in this study we are continuously monitoring the spread of coronavirus. In this study we use a new TOPSIS MCDM approach and GMDH apply to select the significant risk factor and continuous monitoring of death due to Covid-19. Result indicates that “contamination due to contact with the infected person” is the main responsible factor behind the pandemic COVID-19. Also, in this investigation we get an optimal model by which we can monitor the death from Coronavirus within the affected person continuously. Keywords: Coronavirus, risk factor, continuous death monitoring, new TOPSIS approach, GMDH INTRODUCTION In the world of 2020, where WHO has declared Covid-19 to be Pandemic (1), where there is chaos everywhere, people are quarantined, the times square is empty, and so are the other crowded places, where one can find anybody wearing a mask, and with a fear in their eyes–we are literally living through the pages of history books of the future days. Coronavirus has horribly spread across the stretches of the world and too many people are suffering. It’s declared Pandemic by WHO as it is a disease that people are not immune to, spreading throughout the world beyond expectation. Almost 211 countries are suffering (2). More than 72,616 people across the world have lost their lives, and thousands of people are fighting everyday for their lives (2). Countries all over the world are declaring Health emergencies and taking whatever possible steps to keep the citizens safe (3). As the virus is spreading beyond the borders of the countries, we try looking for any possible escape route. Medical Science is doing its best in the search of a possible solution. Doctors and medical staffs all over the world have truly proved themselves to be the unsung hero in this time of chaos by putting themselves in the front line, and by making sacrifices for the sake of humanity (4). So while being in the non–medical field, we still have tried to do our part by trying to contribute a little in the quest. Through the data we have collected do far from Literature surveys, Media websites and by taking medical suggestions, we have chosen three major cause of the spread of Covid-19. It’s mainly spreading through Verbal contamination, contamination through eatables, and contamination due to contact with the infected person. Since we know about quarantine , a situation where a person is asked to isolate or distant himself from crowded places in order to have a safe distance from everyone else, so that there is not contact between him and the outside world, we understand how Contamination through one person to another is taken seriously. Countries all over the world are declaring to keep the schools, colleges closed, to keep down the social gatherings, and suggesting to stay at home. This is very much important not only for others, and for ourselves as well. People are also asked to keep on wearing a mask, to wash their hands again and again. Here hygiene becomes an important thing. The risk factors are leading to panic among the people, creating more chaos as a result. So, our main object of this study to identify the most significant risk factors behind the spread of Coronavirus. Using Multi Criteria Decision Making (MCDM) technique we select that significant risk factor of COVID-19. Multi Criteria Decision Making (MCDM) is most important branch of Operation Research by which people take their complex decision daily life. There are many MCDM tools are modelled by so many researchers. All this MCDM Models are based on behaviour of the decision-making problem. In MCDM process people select the best alternatives with respect to certain criteria. Recently this MCDM tools are used in Economical, Social, Environmental etc (5-7). In MCDM