ResearchArticle Gingivitis Effectiveness of Emulgel Containing 2% Resveratrol in Orthodontic Patients: An 8-Week Randomized Clinical Trial Amin Golshah , 1 Shahla Mirzaeei , 2 Nafiseh Nikkerdar , 3 and Fatemeh Ghorbani 1,4 1 Department of Orthodontic, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran 2 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran 3 Department of Maxillofacial Radiology, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran 4 MedicalBiologyResearchCenter,HealthTechnologyInstitute,KermanshahUniversityofMedicalSciences,Kermanshah,Iran CorrespondenceshouldbeaddressedtoFatemehGhorbani;tima.ghorbani@gmail.com Received 4 December 2020; Revised 15 March 2021; Accepted 21 March 2021; Published 30 March 2021 AcademicEditor:StefanoPagano Copyright©2021AminGolshahetal.isisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Background. Treatment of gingivitis in patients undergoing orthodontic treatment is done through different methods. Anti- inflammatoryagentspresentintoothpasteormouthwashareappliedspontaneouslybypatientsorusedasprofessionaltreatment protocols.epresentstudyaimedtoinvestigatethegingivitiseffectivenessofEmulgelcontaining2%resveratrolinorthodontic patients. Methods.estudywasconductedinthreegroups,namely,experimental,placebo,andcontrol.Intheexperimental group,participantsusedanEmulgelcontaining2%resveratrol.Intheplacebogroup,subjectsusedanidenticalEmulgelwithout theactivecomponentsinthetestformulations.Afterbrushingtheirteeth,theparticipantslearnedhowtouse5mlofEmulgelon thegumsandmassageeverynightfor30s.Inthecontrolgroup,subjectswereinstructedtomassagetheirgumsfor30severynight withoutanyproduct.Evaluatedcriteriaincludedbleedingonprobing(BOP),gingivalindex(GI),hyperplasticindex(HI),and probing pocket depth (PPD). Result.During4and8weeksofthestudy,thePPDscoreinthecontrolgroupdidnotchange significantlybutdecreasedinbothgroups.Also,therewasadecreaseinthePPDscoreintheexperimentalgroupcomparedtothe placeboandcontrolgroups.Similarly,intheexperimentalgroup,continuoususeofEmulgelcontaining2%resveratrolreduced theHIandGIscoressignificantlyat4and8weeksafterthestartofthestudy.Here,thedecreaseinGIandHIscoresinthe experimentalgroupwashigherthanthatoftheothergroups. Conclusions.eEmulgelcontaining2%resveratroliseffectivein improvinggingivalhealthinorthodonticpatientsandcanlowergingivalinflammationover8weeks.istrialisregisteredwith the Iranian registry of clinical trials (https://irct.ir/) IRCT20130812014333N91. 1. Introduction e periodontic-orthodontic interrelationship is still a controversial issue despite numerous studies conducted in this regard [1]. Orthodontic treatments may contribute to enhancing periodontal health because they align teeth and balancedocclusion.erefore,theyimproveoralhygieneby facilitatingaccesstoteeth[2,3].However,fixedorthodontic appliancesmayincreasesupragingivalbiofilmaccumulation anddeteriorateperiodontalhealth[4].Althoughitimproves dentalandskeletalissues,placingtheorthodonticappliances in the patient’s mouth leads to some changes in oral and gingival hygiene habits [5]. Orthodontic forces represent a physical factor triggering an inflammatory response in the periodontium [6]. e clinical manifestations of gingivitis varyintermsoftheseverity,distribution,andresponseto treatment[7].eeffectsobservedbyorthodontics,afterthe placement of orthodontic appliances can cause inflamma- toryhyperplasia,alveolarboneloss(periodontitis),andloss of attached gingival support [8–11]. ere are several methods to treat gingivitis, including anti-inflammatory agentsthatarepresentintoothpasteormouthwashthatare used by patients as professional treatment protocols [11]. Resveratrol (RSV) is a natural multifunctional poly- phenolthathastherapeuticeffectsoninflammatoryagentsat higher concentrations [12, 13]. Resveratrol (3,4,5- Hindawi International Journal of Dentistry Volume 2021, Article ID 6615900, 7 pages https://doi.org/10.1155/2021/6615900