Alginate microsphere compositions dictate different mechanisms of com- plement activation with consequences for cytokine release and leukocyte activation Pontus Ørning, Kine Samset Hoem, Abba Elizabeth Coron, Gudmund Skj˚ ak-Bræk, Tom Eirik Mollnes, Ole-Lars Brekke, Terje Espevik, Anne Mari Rokstad PII: S0168-3659(16)30153-5 DOI: doi: 10.1016/j.jconrel.2016.03.021 Reference: COREL 8183 To appear in: Journal of Controlled Release Received date: 9 December 2015 Revised date: 10 March 2016 Accepted date: 14 March 2016 Please cite this article as: Pontus Ørning, Kine Samset Hoem, Abba Elizabeth Coron, Gudmund Skj˚ ak-Bræk, Tom Eirik Mollnes, Ole-Lars Brekke, Terje Espevik, Anne Mari Rokstad, Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation, Journal of Controlled Release (2016), doi: 10.1016/j.jconrel.2016.03.021 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.