Copyright © Dosso Mamadou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. International Journal of Pharmacology and Toxicology, 8 (1) (2020) 65-69 International Journal of Pharmacology and Toxicology Website: www.sciencepubco.com/index.php/IJPT Research paper Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice Dosso Mamadou 1 *, Coulibaly Adama 1 , Coulibaly Ousmane 2 , Soro Doudjo 2 , N'guessan Jean David 3 1 Department of Biochemistry-Genetics, Péléforo Gon Coulibaly University, BP 1328 Korhogo, Côte d’Ivoire (Ivory Coast) 2 UMRI Food, Chemical and Environmental Process Sciences, Félix Houphouët-Boigny National Polytechnic Institute (INP-HB), BP 1313 Yamoussoukro, Côte d'Ivoire 3 Laboratory Pharmacodynamics Biochemistry, Department of Biosciences, Félix Houphouët-Boigny University 22 BP 582 Abidjan 22 Côte d'Ivoire *Corresponding author E-mail: coatcha1012@gmail.com Abstract This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01- 0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation. Keywords: Saba Senegalensis; Antidiabetic; Hypoglycemic; Antihyperglycemic; Mouse. 1. Introduction Diabetes is a metabolic disease, characterized by chronic hyperglycemia (American Diabetes Association 2002). There are mainly two types of diabetes, 85-90% of which are type II (Dénoue et al. 2016, Kambouche et al., 2011). Unlike Type I, Type II is non-insulin-dependent. Its treatment is based on oral antidiabetic drugs, some of which cause prolonged hypo- glycemia that is just as severe as their complications. These life-long treatments are also expensive, requiring significant resources for their management. Secondary resistance, hypersensitivity and intolerance reactions have also been reported in some patients undergoing antidi- abetic treatment (Marles et al., 1994). For these reasons, new, less expensive molecules with fewer side effects are to be sought. In order to solve their health problems, the African population has chosen medicinal plants, an undeniable source of bioactive molecules (Kambouche et al., 2011, N’Doua et al., 2015). To date, many of these plants have been listed and are the subject of active traditional use (Dénoue et al., 2016). Saba senegalensis, with multiple therapeutic virtues, is one of them; it has large and strong woody liana, with white latex. Saba senegalensis of the family Apocynaceae, which requires a lot of sunlight, is native to tropical Africa (Arbonnier, 2002). It is a Sudanian and Guinean plant, occurring from Senegal to Nigeria via Côte d’Ivoire, Mali and Burkina Faso (Sarr et al., 2018). In traditional medicine, this plant is used against constipation, scleroderma, parasitic infections, headaches and food poisoning. It is also used in the treatment of urinary schistosomiasis and as an antiemetic (Eklu-Natey et al., 2012). Pharmacological data show that the leaves are anti-inflammatory, analgesic, antioxidant (Sarr et al., 2015) and antihelmintic (Magassouba et al., 2007, Traore et al., 2013, Boamponsem et al., 2013). The phytochemical study of the leaves indicates that its aqueous extract contains tannins, saponins and flavonoids (Sarr et al., 2015), chemical groups known for their hypoglycemic properties (Masunda et al., 2014, Kambouche et al., 2009). Aided by this phytochemical content and in order to contribute to the pharmacological study of this plant for which little tangible scientific information is available to date, this study will evaluate: • The hypoglycemic effects of the aqueous extract of the leaves of Saba senegalensis in normo-glycemic mice; and. • The antihyperglycemic agent in mice temporarily hyperglycemic by oral glucose administration (OPGH test). 2. Materials and methods 2.1. Material