S1 Supporting Information for Removal of Endocrine-Disrupting Chemicals from Environment Using A Robust Platform Based on Metal-Organic Framework Nanoparticles Juan Xu, #,† Kaipeng Li, #,‡,§ Sainan Zhang, #,‡ Yao Chen, * ,‡,§ Lifeng Ning* ,† † National Research Institute for Family Planning, Beijing 100081, People’s Republic of China ‡ State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, People’s Republic of China § Department of Pharmacy, Nankai University, Tianjin, 300071, People’s Republic of China *Y. C.: Email: chenyao@nankai.edu.cn; *L. N.: Email: ninglifeng411@126.com Experiment and Materials All chemical reagents were purchased and used without further purification. All estrogens including estradiol, estriol, mifepristone and ethinylestradiol were supported by National Research Institute for Family Planning. Synthesis of MIL-101-R 1-4 Synthesis of MIL-101 and MIL-101-NH 2 FeCl 3 ·6H 2 O (0.675 g, 2.45 mmol) and 1,4-dicarboxylic acid (H 2 BDC) (0.206 g, 1.24 mmol ) were dissolved in 15 mL of DMF. After thermal treatment in an oven at 110 ℃ for 24 h, the product was recovered by centrifugation, and then washed several times with DMF and activated with ethanol for two days (2-3 times one day). Finally, the target product was dried at room temperature. MIL-101-NH 2 material was prepared according to the same protocol, except that 0.225 g (1.24 mmol) of NH 2 -H 2 BDC was used instead of H 2 BDC. Synthesis of MIL-101-Br and MIL-101-NO 2