International Journal of Advances in Pharmacy Medicine and Bioallied Sciences. 2018;6(1)14-21. Original Research Article A study on quality of life and effect of coenzyme-Q10 in polycystic ovarian syndrome patients B.V. S. Lakshmi 1 *, Karuna Bhavani 2 , M. Sudhakar 1 , Heena Parveen 1 . 1 Department of Pharmacology, Malla Reddy College of Pharmacy (Osmania University), Dhulapally, Maisammaguda, Secunderabad-500014, T.S., INDIA. 2 Department of Gynaecology, Malla Reddy Institute of Medical Sciences, Suraram, Hyderabad, T.S., INDIA. A R T I C L E I N F O A B S T R A C T Article History: Received 20 Jan 2018 Revised 10 Feb 2018 Accepted 28 Feb 2018 Background: Polycystic ovarian syndrome, commonly known as PCOs. It is the most common endocrine disorder in women involving cyst formation on ovaries which eventually affects the hormonal imbalance and is now well evidenced with obesity, insulin resistance, hyperandrogenism, abnormal lipid profile and oxidation stress. Subjects and methods: This prospective comparative & interventional study evaluated QOL & effect of CoQ10 in PCOs patients. Results: Out of 40 patients,30 are married and 10 are unmarried.8 are between 18- 22years,13 are between 21-23 years,7 are between 24-26 years,7 are between 27-29 years,3 are between 30-32 years,2 are between 33-35 years.32 are having Irregular menses as major complaint & 8 are having An ovulation as major complaint.20 are between 1-2years of onset of disease,3 are between 2-3 years of onset of disease,7 are between 3-4 years of onset of disease and7 are between 4-5 years of onset of disease.13 are tested with PCOS between 18-22years,9 between 23-27 years,3 between 28-32years & 2 between 33 & above years.10 are suffering from PCOS between 18-22 years,5 are between 23-27 years,2 are between 28-32 years, 2 are between 33 & above years.8 women are aware of infertility due to PCOS between 18-22 years, 3 are between 23-27 years,5 are between 27-32 years,2 are between 33 & above years. Conclusion: The present study revealed that majority of women was aware of PCOS. A few of them already tested themselves for PCOs.CoQ-10 was well tolerated by all the patients and no adverse effects were observed. The lack of any statistically significant differences in the ovulation and clinical pregnancy rates between lean and obese PCOS in the CoQ-10 group suggests that response to CoQ-10 group is independent of body weight, contrary to other methods of ovulation induction. Keywords: Anovulation, Quality of Life, Irregular menses, Clomiphene citrate, CoQ-10 (Co-enzyme Q-10), Antioxidants, PCO. *AUTHOR FOR CORRESPONDENCE E-mail address: adithya.neha@gmail.com Copyright © 2013 Biomedjournal Privacy Policy. All rights reserved. I N T R O D U C T I O N Polycystic Ovarian Syndrome, commonly known as PCOS (Scalzo and McKittrick, 2000). It is the most common endocrine disorder in women involving cyst formation on ovaries which eventually affects the hormonal imbalance in their body (Garad et al., 2011). It has significant reproductive and non-reproductive consequences (Franks. 1995). PCOS is mainly categorized into two types. They are Insulin-Resistant PCOS and Non-Insulin resistant PCOS. Insulin-resistant PCOS is also referred to as Type1 PCOS which include weight gain, facial hair, Ovulatory interruptions, hair loss, acne. Non-insulin resistance PCOS is referred to as Type 2 PCOS but don’t represent with insulin resistance. The main cause of this type of disease is Iodine deficiency, Vitamin-D deficiency, hormone- disrupting toxins, thyroid disease and adrenal stress. PCOS can be classified into tendency, mild form, moderate form, severe form based on the major and International Journal of Advances in Pharmacy Medicine and Bioallied Sciences An International, Peer-reviewed, Indexed, Open Access, Multi-disciplinary Journal www.biomedjournal.com