282 Med J Malaysia Vol 72 No 5 October 2017 ABSTRACT Introduction: The on-going, international, prospective, observational, longitudinal CLARIFY registry is investigating the demographics, clinical profiles, management and outcomes of patients with stable coronary artery disease (CAD). This paper assesses baseline characteristics, treatment, and clinical outcomes at two years’ follow-up of Malaysian/Bruneian patients compared with the overall registry population. Method: Between November 2009 and July 2010, outpatients from 45 countries who met the criteria for stable CAD were recruited into the registry. Baseline characteristics were documented at enrolment, and patients were reassessed during their annual visits over a five-year follow-up period. Key outcomes measured were sudden death and cardiovascular (CV) death, non-CV death and CV morbidity. Results: At baseline, 33,283 patients were available for analysis within the registry; 380 and 27 were Malaysians and Bruneians, respectively. The mean ages of Malaysian/Bruneian patients and the rest of the world (RoW) were 57.83 ±9.98 years and 64.23 ± 10.46 years, respectively (p<0.001). The median body mass index values were 26.6 (24.4-29.6) kg/m 2 and 27.3 (24.8-30.3) kg/m 2 , respectively (p=0.014). Malaysian/Bruneian patients had lower rates of myocardial infarction (54.55% versus 59.76%, p=0.033) and higher rates of diabetes (43.24% versus 28.99%, p<0.001) and dyslipidaemia (90.42% versus 74.66%, p<0.001) compared with the RoW. Measured clinical outcomes in Malaysian and Bruneian patients at 2-years follow-up were low and generally comparable to the RoW. Conclusion: Malaysian/Bruneian patients with stable CAD tend to be younger with poorer diabetic control compared with the RoW. However, they had similar outcomes as the main registry following two years of treatment. KEY WORDS: Coronary artery disease; Malaysia; Brunei; demographics; registry, ischaemic heart disease, heart rate INTRODUCTION Cardiovascular disease (CVD) is the most common cause of mortality in Malaysian Ministry of Health hospitals, accounting for 25.19% of all reported deaths. 1 This is most likely a result of high prevalence of cardiovascular (CV) risk factors such as hypertension, diabetes mellitus, smoking and hyperlipidaemia. In fact, 63% of the Malaysian population had one or more CV risk factors in the Third National Health and Morbidity Survey (NHMS III). 2 A more recent survey of 3,722 low-income relatively young urban dwellers (mean age 41.5 years) also found that 35.1% had hypercholesterolemia, 32.7% had hypertension and 15.2% had diabetes mellitus. 3 Despite the high prevalence of risk factors, we do not have prospective information on clinical characteristic, management and outcome in stable coronary artery disease (CAD) patients in Malaysia. Indeed, in a recent review of coronary artery disease research in Malaysia, most publications instable angina management were either retrospective or limited in a single centre. 4 The international prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary artery disease (CLARIFY) registry was designed to describe the demographics, clinical profiles, management and outcomes of contemporary CAD patients in participating countries, with the intention of identifying gaps between treatment and evidence. 5,6 The registry protocol further recommended that each investigator enrolled between 10-15 consecutive, eligible patients to minimise the risk of selection bias. The rationale, design, and baseline characteristics of CLARIFY have been described previously. 6,7 In this publication, we present the clinical characteristics, management and two-year outcomes of Malaysian and Bruneian patients enrolled in CLARIFY in relation to the rest of the CLARIFY population. We included these two countries in this publication as they share similar geographical and demographical characteristics. MATERIALS AND METHODS Patients with stable CAD receiving standard management were enrolled in 45 countries in Africa, Asia, Australia, Clinical characteristics, treatment and 2-year outcomes in Malaysian and Bruneian patients with stable coronary artery within the worldwide CLARIFY registry Kok Han Chee, MBBS 1 , Gim Hooi Choo, MBBS 2 , Ahmad Nizar Jamaluddin, MD 3 , Kauthaman Mahendran, MRCP 4 , Nicola Greenlaw 5 , Chandran Krishnan, MBBS 6 1 Faculty of Medicine, University of Malaya, Kuala Lumpur, 2 Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia, 3 Ara Damansara Medical Centre, Shah Alam, Selangor, Malaysia, 4 Hospital Melaka, Jalan Mufti Hj Khalil, Melaka, Malaysia, 5 Robertson Centre, University of Glasgow, Glasgow, UK. 6 Department of Medicine, Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia ORIGINAL ARTICLE This article was accepted: 24 September 2017 Corresponding Author: Kok Han Chee Email: drcheekh@gmail.com